新风胶囊对活动期类风湿关节炎患者凝血功能相关指标的影响  

Effects of Xinfeng Capsules on Coagulation Indices in Patients with Active Rheumatoid Arthritis

作　　者：汪元[1] 刘健[1] 张皖东[1] 纵瑞凯[1] 

机构地区：[1]安徽中医药大学第一附属医院风湿病科,安徽合肥230031

出　　处：《安徽中医学院学报》2013年第3期39-42,共4页Journal of Anhui Traditional Chinese Medical College

基　　金：安徽高校省级自然科学研究重点项目(KJ2010A218);国家中医药重点学科中医痹病学建设项目(国中医药发[2009]30号);安徽现代中医内科应用基础与开发研究省级实验室建设项目(科条〔2008〕150号)

摘　　要：目的观察新风胶囊对活动期类风湿关节炎(rheumatoid arthritis,RA)凝血功能及相关炎症指标的影响。方法将60例RA患者随机分为两组,治疗组(新风胶囊)和对照组(来氟米特)各30例,治疗1个疗程,观察治疗前后关节症状、血小板参数、血沉(erythrocyte sedimentation rate,ESR)、C反应蛋白(C-reac-tion protein,CRP)、类风湿因子(rheumatoid factors,RF)、免疫球蛋白G(immunoglobulin G,IgG)及凝血酶原时间prothrombin time,PT)、活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、血浆纤维蛋白原(plasma fibrinogen,FIB)、凝血酶时间(thrombin time,TT)及血浆D-二聚体(d-dimer,DD)等凝血指标变化。结果两组均能显著降低关节疼痛数、关节压痛数、ESR、CRP、IgG水平,治疗组在关节肿胀数、晨僵时间、血小板计数、血小板比容、血小板平均体积、FIB、DD等方面均显著降低,与对照组比较,差异有统计学意义(P<0.05,或P<0.01)。结论新风胶囊降低RA患者PLT、FIB及DD,改善RA患者凝血功能异常,减轻瘀血阻络证候,可能是其改善RA患者关节症状的重要途径之一。Objective To observe the effects of Xinfeng Capsules on the coagulation indices and related inflammatory indices in patients with active rheumatoid arthritis （RA）. Methods Sixty RA patients were randomly divided into treatment group （n=30） and control group （n=30） to receive Xinfeng Capsules and leflunomide, respectively, for one course of treatment. The therapeutic effects were assessed based on the changes in articular symptoms, platelet parameters, erythrocyte sedimentation rate （ESR）, C-reaction protein （CRP）, rheumatoid factors, immunoglobulin G （IgG）, prothiombin time, activated partial thromboplastin time, plasma fibrinogen （Fib）, thrombin time, and plasma D-dimer （DD） after treatment. Results After treatment, both groups showed significant decreases in incidence of joint pain and joint tenderness, ESR, and CRP and IgG levels; the treatment group showed significant decreases in incidence of joint swelling, time of morning stiffness, platelet count, thromboeytocrit, mean platelet volume, and plasma Fib and DD levels and had a significantly better treatment outcome than the control group in terms of these indices （P〈0.05 or P〈0.01）. Conclusion Xinfeng Capsules can decrease platelet count and plasma Fib and DD levels, improve coagulation function, and relieve the syndrome of blood stasis obstructing the collaterals, which may be one of the important reasons why Xinfeng Capsules alleviate the articular symptoms in RA patients

关 键 词：新风胶囊 类风湿关节炎 凝血功能 

分 类 号：R593.22[医药卫生—内科学]