丙泊酚和依托咪酯在胃镜检查中的应用  

Application of propofol and etomidate in gastroscopy

作　　者：朱宇航[1] 朱昭琼[1] 郑淑文[1] 闫薇[1] 张帆[1] 李娟[1] 

机构地区：[1]遵义医学院附属医院麻醉科,贵州遵义563099

出　　处：《遵义医学院学报》2013年第2期141-144,共4页Journal of Zunyi Medical University

基　　金：贵州省科技厅资助项目(NO:黔科合J字[2007]2132);山东鲁南制药集团资助项目(NO:遵鲁药[2010]001号)

摘　　要：目的对比观察130例丙泊酚和依托咪酯在胃镜检查中的麻醉效果及不良反应。方法丙泊酚组(P组,n=65)2～4 mg/kg静注,依托咪酯组(E组,n=65)0.15～0.5 mg/kg静注。观察:①麻醉前(T1)、麻醉起效时(T2)、胃镜过食道入口(T3)、检查中(T4)、胃镜退出食道入口(T5)及苏醒即刻(T6)的RR、HR、SPO2。②上述各时点不良反应。③苏醒方式及离院时间。④手术/麻醉医生、护士及家属满意度。结果①两组RR、HR、SPO2在正常范围内波动。②注射痛P组较E组明显增多(P<0.05),局部肌颤、体动E组高于P组(P<0.05),其余各项均无统计学差异(P>0.05)。③两组患者苏醒及离院时间均无统计学差异(P>0.05)。④手术/麻醉医生、护士的满意度P组优于E组(P<0.05)。结论丙泊酚和依托咪酯用于胃镜检查效果良好,不良反应持续时间短,无严重不良事件发生。Objective To explore and compare the anesthetic effects and adverse reactions of propofol and etomidate on 130 patients undergoing painless gastroscopy. Methods One hundred and thirty patients were randomly divided into propofol group （group P, n = 65 ） with,intravenous injection of propofol （2 -4 mg/kg） and etomidate group （group E, n = 65 ） with intravenous injection of etomidate （0.15 -0. 5 mg/kg）. The RR, HR and SpO2values and adverse reactions were recorded , respectively, in the fol- lowing periods of pre - anesthesia （ T1 ）, anesthetics coming into effect （ T2 ）, gastroscope passing through esophageal entrance （T3）, examining period （T4）, gastroscope withdrawing from esophageal entrance （TS） and palinesthesia moment （T6）. Palinesthesia patterns and hospital discharge and the satisfactory degree of surgeons, anesthetists, nurses and family members were also recorded. Results 1. The RR, HR and SpO2values in two groups fluctuated among the normal range. 2. Group P had shown more injection pains than group E （P 〈 0.05 ）, More local amyostasia and body movement were indica- ted in group E than in group P （ P 〈 0, 05 ）. 3. There was no significant difference of palinesthesia pat- terns and hospital discharge（P 〉 0.05 ）. 4. The satisfactory degree of surgeons, anesthetists, nurses and family members in group P was better than that in group E （ P 〈 0.05 ）. Conclusion Propofol and etomi- date could be better used in painless gastroscopy with short time adverse reactions and no any severe ad- verse events happened.

关 键 词：丙泊酚 依托咪脂 日间麻醉 无痛胃镜 不良反应 

分 类 号：R614.2[医药卫生—麻醉学]