不同剂量地塞米松治疗急性低频下降型感音性聋疗效比较  

The clinical effect of different dose dexamethasone on acute low-frequency sensorineural hearing loss

作　　者：林君[1] 

机构地区：[1]山东省邹平县人民医院耳鼻喉科,256200

出　　处：《中国基层医药》2013年第12期1832-1834,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 比较不同剂量地塞米松治疗急性低频下降感音神经性聋（ALHL）的临床疗效。方法 266例ALHL患者按就诊顺序分为治疗组（136例）与对照组（130例）,两组在综合治疗的基础上,治疗组给予地塞米松40 mg/d静脉滴注,对照组给予地塞米松20 mg/d,比较两组治疗效果、平均听阈及复发情况。结果 治疗组治愈率为30.8%（42/136）、有效率为50.0%（78/136）、无效率为19.2%（36/136）、总有效率为80.8%,对照组治愈率为26.1%（34/130）、有效率为52.2%（68/130）、无效率为21.7%（28/130）、总有效率为78.3%,两组总有效率差异无统计学意义（χ2=0.14,P＞0.05）。治疗后,两组在125Hz、500Hz频段的平均听阈值差异均有统计学意义（均P＜0.05）。治疗组出现19例复发（19/120）,对照组出现8例（8/102）复发,两组复发率差异有统计学意义（t=2.241,P＜0.05）。结论 地塞米松治疗ALHL效果显著,小剂量地塞米松术后复发率低,无严重并发症出现。Objective To compare the clinical effect of different dose dexamethasone on acute low-frequency sensorineural hearing loss （ALHL）.Methods 266 cases with ALHL were randomly divided into treatment group （136 cases） and control group （130 cases）.On the basis of the comprehensive treatment,the treatment group received dexamethasone 40mg/d intravenous infusion,the control group was given dexamethasone 20mg/d.The treatment effect,average hearing threshold and recurrence were compared between the two groups.Results In the treatment group,the cure rate was 30.8%（42/136）,the effective rate was 50.0%（78/136）,invalid rate was 19.2%（36/136）,the total effective rate was 80.8%.In the control group,the cure rate was 26.1%（34/130）,the effective rate was 52.2%（68/130）,the invalid rate was 21.7%（28/130）,the total effective rate was 78.3%,the total effective rate between the two groups had no statistically significant difference （χ2=0.14,P〉0.05）.After treatment,125Hz,500Hz band,the average hearing threshold between the two groups had statistically significant differences （P〈0.05）.19 patients relapsed（19/120） in treatment group,the control group had a recurrence of 8 patients（8/102）,the recurrence rate between the two groups had statistically significant difference （t=2.241,P〈0.05）.Conclusion Dexamethasone has good effect in treatment of ALHL.Small dose dexamethasone can reduce the recurrence rate and has no serious complications.

关 键 词：聋 听阈 地塞米松 

分 类 号：R764[医药卫生—耳鼻咽喉科]