乌司他汀对急性肺损伤患者C反应蛋白及基质金属蛋白酶-9的影响  

Effect of ulinastatin on C-reactive protein and matrix metalloproteinase-9 in patients with acute lung injury

作　　者：梁丽萍[1] 潘勇翔 陈毓青[1] 陆慧慧[1] 易玉芳[1] 

机构地区：[1]桂林医学院附属医院老年科,广西桂林541001 [2]桂林市第二人民医院急诊科,广西桂林541001

出　　处：《华夏医学》2013年第1期28-30,共3页Acta Medicinae Sinica

摘　　要：目的:探讨急性呼吸窘迫综合征(ARDS)患者血C反应蛋白(CRP)和基质金属蛋白酶9(MMP-9)水平的变化及乌司他丁对其的影响。方法:对40例收入ICU内的ARDS患者分为乌司他丁治疗组和对照组,治疗组给予乌司他丁20万U+生理盐水100ml,2次/d静脉注射,其余治疗方案两组均相同,然后对两组患者血CRP和MMP-9水平、呼吸频率、氧合指数(PaO2/FiO2)、PaO2进行测定。结果:两组患者治疗前呼吸频率、PaO2、PaO2/FiO2、年龄及CRP、MMP-9水平均无显著性差异;乌司他丁治疗可显著减少ARDS患者血CRP、MMP-9的表达(P<0.01),显著改善ARDS患者的呼吸情况(P<0.001)。结论:乌司他丁可抑制ARDS的CRP、MMPs表达和改善呼吸情况,对ARDS患者有保护作用。Objective： To investigate the changes of the blood c-reactive protein （CRP） and matrix metalloproteinase-9 （MMP-9） levels in patients with acute respiratory distress syndrome （ARDS） and the effect of ulinastatin on them. Methods： 40 ADRS patients admitted into ICU were divided into the ulinastatin treatment group and the control group. Patients in the ulinastatin treatment group were intravenously injected with 2× 10^6 U ulinastatin ＋100 ml 0. 9% normal saline （NS）, twice a day. The other treatment plan for both group was the same. Then The levels of blood （CRP） and MMP-9, respiratory rate, oxygenation index （PaO/FiO2）, and PaO2 in both groups were determined. Results： There were no significant differences in the respiratory rate, oxygena- tion PaO2 ,PaO/FiO2, ages and the levels of CRP and MMP-9 in patients of both groups before the treatment. Ulinastatin treatment could reduce the expressions of CRP and MMP-9 in patients with ARDS （P〈0.01）, and greatly improve the patients＇ respiration （P〈0. 001）. Conclusion： Ulinas- tatin can inhibit the So ulinastatin has a expressions of CRP and MMP-9 and improve the respiration of ARDS patients. protective effect on patients with ARDS.

关 键 词：急性呼吸窘迫综合征 基质金属蛋白酶 C反应蛋白 乌司他汀 

分 类 号：R563.8[医药卫生—呼吸系统]