应用rhBMP-2行脊柱后侧方固定的研究  

Study on Spinal Posterolateral Fussiou with rhBMP-2

作　　者：李仙锋[1] 唐英翰[1] 林欣[1] 

机构地区：[1]哈尔滨医科大学附属二院骨科,150086

出　　处：《伤残医学杂志》2000年第2期1-2,共2页Medical Journal of Trauma and Disability

摘　　要：目的：探讨应用ｒｈＢＭＰ－２（重组人骨形态发生蛋白－２）行脊柱后侧方固定的可能性．方法：用ｒｈＢＭＰ－２与ＰＶＰ（聚乙烯吡咯烷酮）制成复合物，注入２８只白兔右Ｌ４／５水平横突间肌肉中，对侧单独注入ＰＶＰ作为对照，分别在２、４、６和８周取材，作Ｘ线、组织形态学、碱性磷酸酶（ＡＬＰ）及电镜检测．结果：ｒｈＢＭＰ－２ＰＶＰ复合物具有良好的骨诱导活性，新生骨在横空间可完全愈合．结论：作者认为应用ｒｈＢＭＰ－２能够完成脊柱后侧方固定，复合物可望在临床上应用于脊柱后侧方固定．Objective: To study the possibility of spinal fussion with rhBMP-2 (Recombinant human bone morphogenetic protein-2). Methods: The compounds containing 1mg rhBMP and PVP were injected into the muscle between right L4/5 transverse process of rabbit. PVP was respectively injected into the opposite site as controls. The samples were obtained in 2, 4, 6 and 8 weeks, and were observed with X-ray, histomorphological and alkaline phosphatase (ALP) activities. Results: The compounds possessed osteo-inductive potential. The new bone formation could get osseous tissue healing between the transverse process. Conclusion: The spinal posterolateral fussion could be achieved by rhBMP2/PVP and the compounds could be used in clinic.

关 键 词：骨形态发生蛋白 脊柱固定 载体 

分 类 号：R687.34[医药卫生—骨科学]