Amicoumacin类抗生素的研究进展  

Research Progress of Amicoumacin Group Antibiotic

作　　者：韩晓艳[1,2] 刘少伟[2] 王飞飞[2] 刘佳萌[2] 陈川[2] 胡辛欣[2] 蒋忠科[2] 游雪甫[2] 尚广东[3] 张玉彬[1] 孙承航[2] 

机构地区：[1]中国药科大学生命科学与技术学院,南京210009 [2]中国医学科学院&北京协和医学院医药生物技术研究所,北京100050 [3]南京师范大学生命科学学院,南京210023

出　　处：《国外医药（抗生素分册）》2013年第3期106-115,共10页World Notes on Antibiotics

基　　金：国家自然科学基金(NO.81172963);高等学校博士学科点专项科研基金博导类项目(NO.20111106110032);十二五"重大新药创制"科技重大专项(NO.2012ZX09301-002-001-018);2012年中国医学科学院医药生物技术研究所中央级公益性科研院所基本科研业务专项(NO.IMBF201204)

摘　　要：Amicoumacin类抗生素是由微生物产生的异香豆素类化合物,其化学结构独特,生物活性广泛,是微生物药物的重要来源。自1975年第一个明确化合物结构的amicoumacin类化合物报道至今,国内外尚无该类化合物研究进展的综述。针对国内外amicoumacin类化合物研究进展结合本课题组最新研究结果,本文首次对该类化合物产生菌来源、化合物结构、生物活性和生物合成途径等各方面进展进行了较全面的总结。Amicoumacin group antibiotic is a type of isocoumarin compounds produced by microorganisms as the secondary metabolites. Their unique chemical structures and broad spectrum of biological activities made them important sources for microbial agents. From the first structurally identified member of amicoumacin group antibiotic reported in 1975, more than 29 members were reported till now, but none review on the group of antibiotic was published domestically and internationally. Here, we retrospect and summarized their chemical structures, origin of producing strains, biosynthetic pathway, biological activities, etc.. Meanwhile, the latest research progress made by our group on how to discover new member of amicoumacin by LC-DAD-MS dereplication was also summarized.

关 键 词：Amicoumacin 异香豆素 微生物 化学结构 生物活性 

分 类 号：R978.1[医药卫生—药品]