输血对血清铁蛋白、叶酸和维生素B12短期水平的影响  

The effects of blood transfusion on serum ferritin,folic acid,and vitamin B12 levels in short term

作　　者：何婉婷[1] 刘志宇[1] 张茗文[1] 王连杰[1] 赵秀峰 王巍[1] 

机构地区：[1]哈尔滨医科大学附属第一医院血液内科,黑龙江哈尔滨150001 [2]牡丹江红旗医院肿瘤科,黑龙江牡丹江157011

出　　处：《哈尔滨医科大学学报》2013年第2期168-170,共3页Journal of Harbin Medical University

基　　金：黑龙江省青年科学基金资助项目(QC2010019);黑龙江省博士后科研启动金(LBH-Q10031);黑龙江省教育厅新世纪人才项目(1252-NCET-014)

摘　　要：目的评估在输血前及输血后短时间(3天)血清铁蛋白、叶酸和维生素B12浓度的变化,以证明输血是否能够干扰这些营养素的血清浓度。方法采用免疫比浊法和化学发光微粒子免疫检测法检测30例慢性贫血患者输注2 U红细胞悬液前、输注后第1天和第3天血清铁蛋白、叶酸和维生素B12浓度的变化。结果在输注红细胞后3天内血红蛋白水平较输注前增高(P<0.001),血清铁蛋白、叶酸和维生素B12水平无显著变化(P>0.05)。结论输血对输血后3天内血清铁蛋白、叶酸和维生素B12水平的影响甚微,故输血后1～3天内采血对于诊断营养缺乏性贫血不受影响。Objective To evaluate the influence of blood transfusion on the serum levels of dif- ferent nutrients, serum ferritin, folic acid, and vitamin B12 levels. Methods Thirty patients with anemia of various causes received packed red cell transfusions. Immunoturbidimetry and chemiluminescent microparticle immunoassay （CMIA） were used to detect the concentration of these nutrients before and after （thel st and the 3rd day） blood transfusion. Results The he- moglobin level was higher than that before transfusion（ P 〈 0. 001 ） , but no significant change was found in serum ferritin, folic acid, and vitamin Bi2 levels before or at any time after blood transfusion（P 〉 0.05 ）. Conclusion Blood transfusion exerts little effect on the serum levels of ferritin, folic acid, or vitamin B12. Moreover, the blood for testing drawn 1 to 3 days after transfusion could not affect the diagnosis of nutritional deficient anemia.

关 键 词：输血 铁蛋白 叶酸 维生素B12 

分 类 号：R457.1[医药卫生—治疗学]