唇腺病理阳性判定方法对干燥综合征的诊断价值  

Value of positive labial salivary glands pathology results in diagnosing Sjgren's syndrome

作　　者：李娅[1] 费允云[1] 张文[1] 赵岩[1] 张奉春[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院风湿免疫科,北京100730

出　　处：《基础医学与临床》2013年第6期671-674,共4页Basic and Clinical Medicine

基　　金：国家十一五科技支撑计划(2008BAI59B03);卫生部行业基金(201202004)

摘　　要：目的探讨不同判定方法得出的唇腺病理阳性结果对干燥综合征(SS)诊断的影响。方法收集2009年1月至2010年10月北京协和医院风湿免疫科诊断为SS,且唇腺病理阳性的患者21例,其中10例唇腺标本符合灶性淋巴细胞浸润性唾液腺炎(FLS)表现,灶性指数(FS)≥1(A组),余11例唇腺标本中见到≥50个淋巴细胞于间质聚集(B组)。收集患者临床资料,采用独立样本t检验、卡方检验评价不同检测方法得出的唇腺病理阳性结果对SS患者疾病活动和脏器损伤的影响。结果 1)A组患者关节痛发病率显著高于B组(P<0.01),其他临床特征间无差异。2)A组患者左眼BUT低于B组,左眼角膜染色着色斑数目高于B组,左眼角膜染色阳性率高于B组(P<0.05)。3)两组患者高滴度ANA、抗SSA抗体、抗SSB抗体阳性率无差异。结论两种判定方法得出的唇腺病理阳性结果对SS的诊断无明显差异。Objective To detect the effect of positive labial salivary glands pathology results derived from different methods for diagnosis of SjiSgren＇s syndrome（SS）. Methods From January 2009 to October 2010, 21 patients with SS and positive labial salivary glands pathology were studied. Ten biopsies were focal lymphocytic sialadenitis （FLS） , with focus score （FS） I〉 1 （group A）. The presence of focal infiltrates of lymphocytes in labial gland in terstitial tissue was defined as positive in the other 11 biopsies （group B ）. Clinical student＇s t-test, chi-square test were used to evaluate the effect of positive labial glands data were collected, and pathology results derived from different methods for diagnosis of SS. Results 1 ） The positive rate of arthralgia was significantly higher in group A than group B （P 〈0. 01 ）. 2） Group A＇s left eye BUT was lower than group B, and the number of corneal fluorescein staining spot was more than that in group B, while the positive rate of left corneal staining was higher than group B （P 〈 0. 05 ）. 3 ） There was no difference between two groups in positive rates of high titer ANA and anti-SSA/SSB antibodies. Conclusions The labial salivary glands pathology derived from the two methods had no obvious difference in diagnosing SS.

关 键 词：干燥综合征 唇腺病理 灶性淋巴细胞浸润性唾液腺炎 灶性指数 

分 类 号：R593.2[医药卫生—内科学]