皮质下动脉硬化性脑病的扩散张量成像分析  

Diffusion tensor imaging analysis in subcortical arteriosclerotic encephalopathy

作　　者：郑欣[1] 贾洪远[2] 史浩[1] 

机构地区：[1]山东大学附属千佛山医院影像科,山东济南250014 [2]山东省泰安市岱岳区妇幼保健院

出　　处：《实用放射学杂志》2013年第5期704-707,共4页Journal of Practical Radiology

摘　　要：目的探讨扩散张量成像（DTI）技术在皮质下动脉硬化性脑病（SAE／BD）中的应用价值。方法对经临床诊断的40例BD患者和40例健康老年人行常规MRI及DTI检查，测量BD组常规MRI表现阳性病灶区、BD组表现正常脑白质区及对照组正常脑白质3组平均弥散系数（DCavg）值、各向异性分数（FA）值，进行统计学分析，并研究二者之间的相关性。结果BD病灶区FA值降低、DCavg值增高，与对照组脑白质差异均有统计学意义（P〈0．05）；BD正常脑自质区FA值与正常对照组相比有所降低、DCavg值有所增高，且差异有统计学意义（P〈0．05），3组的DCavg值与FA值均具有相关性。结论DTI检查BD．其DCavg、FA值显示出特征性的改变，即DCavg值增高，FA值降低，并能够发现常规MRI检查正常的脑白质微结构改变。Objective To investigate the value of diffusion tensor imaging（DTI） in evaluation of subcortical arteriosclerotic en- cephalopathy（SAE/BD}. Methods Routine MRI and DTI were performed in 40 cases with BD and 40 healthy elder as a control group. DCavg and FA were detected, calculated and analyzed statistically in the lesions of BD, normal white matter area of BD and normal white matter area of the control group. Results FA decreased, DCavg increased in BD lesions and there was a significant difference between BD lesions and the white matter of the control group （P〈0.05）. FA decreased, DCavg increased in normal white matter of BD compared with the control group and there was a significant difference between them （P〈0.05 ）. DCavg was correlated to FA in BD lesions, normal white matter area of BD and the control group. Conclusion The characteristic changes of DCavg and FA values are detected during the examination of BD with DTI, i.e. DCavg increased and FA decreased. Also, DTI might detect the the microstructural changes of white matter while routine MRI results are normal.

关 键 词：磁共振成像 扩散张量成像 血管性痴呆 皮质下动脉硬化性脑病 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742[医药卫生—诊断学]