TSG-6在病理性瘢痕中的表达及意义  

Expression of TSG-6 and its significance in pathological scar

作　　者：洪学哲[1] 李小静[1] 宁金龙[1] 

机构地区：[1]安徽医科大学第一附属医院整形外科,合肥230022

出　　处：《安徽医科大学学报》2013年第6期685-687,共3页Acta Universitatis Medicinalis Anhui

基　　金：安徽省自然科学基金(编号:11040606M202);国家自然科学基金(编号:81272107)

摘　　要：目的观察肿瘤坏死因子-α刺激基因-6(TSG-6)在病理性瘢痕组织中的表达,并探讨其在瘢痕形成中的作用。方法收集临床标本30例,其中增生性瘢痕10例(A组)、瘢痕疙瘩10例(B组)、正常皮肤10例(C组),采用免疫组化法以及逆转录聚合酶链反应(RT-PCR)法检测TSG-6在各组中的表达并进行统计学分析。结果 A、B组中TSG-6蛋白及mRNA呈高表达,与C组比较,差异有统计学意义(P<0.05),TSG-6主要定位于成纤维细胞。结论 TSG-6的表达与病理性瘢痕的形成机制有密切关系,这为防治病理性瘢痕形成提供了新的治疗靶点。Objective To observe the the expression of tumor necrosis factor alpha stimulated gene-6 （TSG-6） in pathological scar and explore its effect on formation of pathological scar. Methods Tissue specimens from 10 cases of hypertrophic scar （group A）, 10 cases of keloid （group B） and 10 cases of normal skin （group C） were collected. Immunohistochemistry and RT-PCR techniques were performed to detect the expression and localization of TSG-6. And then data were statistically analyzed. Results The expressions of TSG-6 in groups A and B were higher than those in group C, and groups A and B showed significant differences from group C （P 〈 0. 05）. Moreover, TSG-6 mainly expressed in fibroblasts. Conclusion The mechanism of pathological scar formation is associated with the expression of TSG-6. TSG-6 may inhibit the formation of pathological scar by inhibiting MMP-9 and inflammatory reaction, which may provide a new target for the prevention and cure of the pathological scar formation.

关 键 词：TSG-6 病理性瘢痕 瘢痕疙瘩 增生性瘢痕 成纤维细胞 

分 类 号：R392.11[医药卫生—免疫学]