获得性血友病A确诊前病程分析  

Analysis of the clinical features of acquired hemophilia A

作　　者：马庆辉[1] 李含[1] 李强[1] 刘阳[1] 秦芳梅[1] 张钰[1] 范志平[1] 孙竞[1] 

机构地区：[1]南方医科大学南方医院血液科,广东广州510515

出　　处：《热带医学杂志》2013年第5期624-627,共4页Journal of Tropical Medicine

基　　金：广东省自然科学基金(S2011010003897)

摘　　要：目的分析获得性血友病A(AHA)诊治的临床特点,探讨国内外治疗该病的差异。方法整理分析2007-2012年本院收治的9例AHA患者资料,对比近5年国内AHA相关文献及欧洲获得性血友病登记管理组织(EACH2)的研究结果,分析国内外AHA确诊前病程与完全缓解率(CR)的差异。结果本组9例及国内文献100例AHA患者确诊前病程均延迟于EACH2的研究报道,CR率也均低于后者,差异具有统计学意义(P<0.05)。结论我国AHA患者治疗状况与欧洲国家存在差异,加大知识宣传,降低漏诊、误诊率可能有助于缩短差距。Objective To compare the clinical features and the treatment methods of acquired hemophilia A （AHA）. Methods Clinical data, including the courses of disease development before diagnosis and the complete remission rate （CR）, of 9 AHA patients from Nanfang hospital from 2007 to 2012 were retrospectively analyzed. The data were also compared with the report from the domestic literatures which were published in the past 5 years and the study results from the Europe Acquired Hemophilia Registry Management Organization （EACH2）. Results There were statistically significant differences between China and European countries on the courses before diagnosis and rate of CR in AHA （P 〈0.05）.Conclusions There was a significant different in the treatment of AHA patients between China and European countries.Enhancing the understanding of AHA, avoiding the missed diagnosis and misdiagnosis may improve the treatment of AHA.

关 键 词：获得性血友病A 凝血因子VH C 确诊前病程 

分 类 号：R544.1[医药卫生—心血管疾病]