补肾中药在干细胞培养与移植中的干预作用  

Revealing nourishing kidney drugs in the culture and differentiation of stem cells

作　　者：高月彩[1] 李蒙[2] 李瑞玉[3] 孙艳孚 

机构地区：[1]邢台医学高等专科学校第二附属医院急诊科,河北省邢台市054000 [2]武警新疆总队和田地区支队卫生队,新疆维吾尔自治区和田市848011 [3]邢台医学高等专科学校第二附属医院中西医结合研究所,河北省邢台市054000

出　　处：《中国组织工程研究》2013年第14期2609-2616,共8页Chinese Journal of Tissue Engineering Research

基　　金：河北省中医药管理局资助项目(2012068)~~

摘　　要：背景:干细胞移植的不断改进和对传统中医理论认识的不断深入,促进了补肾中药干预干细胞分化的研究。目的:探讨补肾中药在干细胞培养与移植中的干预作用。方法:收集干细胞移植治疗疾病过程加入不同类别单味或复方补肾中药起到的促进干细胞增殖分化、诱导分化的作用等相关研究,进行实验数据分析,应用血清药理学原理评估补肾中药在干细胞培养与移植中的干预作用。结果与结论:加强补肾中药与干细胞的基础研究,在现有新理论基础上,继续深化相关的基础理论研究,使补肾中药与干细胞研究有科学的理论指导,在干细胞增殖、分化及转分化机制研究的基础上,筛选能调节干细胞不同发育阶段的补肾中药。在此初步筛选的基础上,结合临床应用中已经取得的成果,才能有针对性地选定相关的单味或复方补肾中药,研究其对干细胞移植治疗重大疾病的干预作用。BACKGROUND： The continuous improvement of stem cell transplantation and understanding of the traditiona Chinese medicine theory can strengthen the research regarding the effect of nourishing kidney drugs on the differentiation of stem cells. OBJECTIVE： To investigate the interventional effect of nourishing kidney drugs on stem cell culture and transplantation. METHODS： The relative studies on different categories of single herb or compound nourishing kidney drugs for the proliferation, differentiation and induction of stem cells during stem cell transplantation for the treatment of diseases were collected to analyze the experimental data, and to evaluate the interventional effect of nourishing kidney drugs on the stem cell culture and transplantation based on serum pharmacology. RESULTS AND CONCLUSION： According to the basic research on nourishing kidney drugs and stem cells, and based on the existing new theory, the basic theoretical research was deepened continuously, in order to provide scientific theoretical guidance for the research on nourishing kidney drugs and stem cells. Based on the researches on the proliferation, differentiation and transdifferentiation mechanism of stem cells, the nourishing kidney drugs that could regulate stem cell growth were screened out. Then, combined with the achievement obtained from the clinical application, the single herb or compound nourishing kidney drugs were selected targetedly, and the interventional effect of the drugs on stem cell transplantation in the treatment of major diseases was analyzed.

关 键 词：干细胞 干细胞学术探讨 补肾中药 骨髓干细胞 骨髓基质细胞 骨髓间充质干细胞 造血干细胞 神经干细胞 肝细胞 成骨细胞 动物实验 增殖分化 免疫组化 诱导 体外培养 血管生成 省级 基金 

分 类 号：R318[医药卫生—生物医学工程]