镁锌合金植入动物体内的分子生物相容性  

Molecular biocompatibility of a magnesium-zinc alloy implanted in animals

作　　者：袁青领[1] 阎钧[2] 郑起[2] 张绍翔[3] 张小农[3] 

机构地区：[1]郑州大学第一附属医院甲状腺外科,河南省郑州市450052 [2]上海交通大学附属第六人民医院普外科,上海市200233 [3]上海交通大学材料科学与工程学院,上海市200240

出　　处：《中国组织工程研究》2013年第16期2921-2926,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(30901422)~~

摘　　要：背景:前期研究显示镁锌合金长期植入动物体内有较好的生物安全性。目的:观察将镁锌合金植入大鼠盲肠的分子生物相容性。方法:取72只SD大鼠,随机分成假手术组、纯钛组和镁锌合金组,每组24只。假手术组仅做盲肠切开缝合,纯钛组在盲肠切口周围包埋医用纯钛,镁锌合金组在盲肠切口周围包埋镁锌合金。手术前后检测血清谷丙转氨酶、肌酐、镁离子浓度及血小板衍化生长因子浓度,以及盲肠组织中转化生长因子β1表达情况。结果与结论:术后相同时间点3组间血清谷丙转氨酶、肌酐、镁离子浓及血清血小板衍化生长因子浓度,以及盲肠组织中转化生长因子β1表达差异无显著性意义(P>0.05)。镁锌合金组术后不同时间点血小板衍化生长因子浓度明显高于术前水平(P<0.05)。表明镁锌合金对大鼠肠道伤口愈合无明显影响,在肠道内有较好的分子生物相容性。BACKGROUND：Previous studies have shown that long-term implantation of magnesium-zinc al oy into animals has a good bio-security. OBJECTIVE：To observe the molecular biocompatibility of biodegradable magnesium-zinc al oy samples implanted into the rat cecum. METHODS：Seventy-two Sprague Dawley rats were randomly divided into magnesium-zinc al oy group, medical titanium group and sham-operated group, and there were 24 rats in each group. Then magnesium-zinc al oy samples were embedded in the cecum incision in the magnesium-zinc al oy group. The medical titanium was embedded in the medical titanium group, and just suture was done in the sham-operated group. Prior to and after surgery, alanine transaminase, creatinine, magnesium ion concentrations, serum platelet-derived growth factor concentration and the expression of transforming growth factor-β1 in the cecal tissue were detected by immunohistochemistry. RESULTS AND CONCLUSION：No significant difference was determined in serum aspartate aminotransferase, creatinine, and magnesium ion concentrations, serum platelet-derived growth factor concentration and the expression of transforming growth factor-β1 among the magnesium-zinc al oy group, medical titanium group and sham-operated group at the same time point fol owing surgery （P〉0.05）. However, in the magnesium-zinc al oy group, the level of serum platelet-derived growth factor was significantly increased at different time after surgery （P〈0.05）. The magnesium-zinc al oy had no harmful effect on wound healing of the rat cecum, and posed a good biocompatibility with the rat cecum.

关 键 词：生物材料 材料生物相容性 镁锌合金 纯钛 伤口愈合 分子生物相容性 盲肠 丙转氨酶 肌酐 镁离子 血小板衍化生长因子 转化生长因子β1 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]