多种抗菌剂抗菌性及混合加入复合树脂的抗菌性能  

Antimicrobial composite resin: Antibacterial ability

作　　者：车小强[1] 张松营[1] 陈云平[1] 刘斌[1] 

机构地区：[1]兰州大学口腔医学院,甘肃省兰州市730000

出　　处：《中国组织工程研究》2013年第16期3002-3009,共8页Chinese Journal of Tissue Engineering Research

基　　金：甘肃省科技支撑计划(1204FKCA180);甘肃省科技计划项目(1107RJYA002);兰州大学口腔医学院科研扶持基金(2011-07)~~

摘　　要：背景:抗菌剂如纳米载银、季胺盐、磷酸钙等,具有良好的抗菌作用,能对口腔中常见致病菌的生长起到抑制作用,将抗菌剂作为填料加入复合树脂,制成抗菌性复合树脂,是当前研究的一个热点。目的:综述近年国内外关于抗菌性复合树脂的研究情况。方法:以"复合树脂,抗菌剂,银离子,季胺盐,磷酸钙"为中文关键词,以"composite resin,antibacterialagent,silver ion,amine salt,calcium phosphate"为英文关键词,采用计算机检索1995年1月至2012年5月中国知网数据库CNKI、PubMed数据库和维普中文科技期刊数据库、万方数据库、Web ofScience期刊引文索引数据库及Nature数据库有关抗菌性复合树脂的文献。结果与结论:抗菌剂分为天然、有机、无机、有机高分子抗菌剂。目前研究较多的有纳米载银抗菌性复合树脂、季铵盐抗菌性复合树脂、纳米磷酸钙抗菌性复合树脂等。体内外实验表明,抗菌剂的加入使复合树脂具有较强的抗菌性能,可阻断细菌的生长过程,进而减少继发龋的发生,延长修复体的寿命,且不改变复合树脂的理化性质。最新的研究中将多种不同性质的抗菌剂混合加入复合树脂中得到了具有更强抗菌性、机械性能的抗菌性复合树脂,这也将成为今后研究新型抗菌性复合树脂的重要方向。BACKGROUND：Antibacterial agents with good antibacterial effects, such as nano silver, amine salt, and calcium phosphate, have a growth inhibition on common pathogenic bacteria in the mouth. Recently, it is a hot issue to make antimicrobial composite resins by adding the antibacterial agents to the composite resin. OBJECTIVE：To summarize recent studies on antimicrobial composite resin. METHODS：Databases of CNKI, PubMed, Wanfang, VIP, Web of Science, and Nature from January 1995 to May 2012 were searched by computer with key words of“composite resin, antibacterial agent, silver ion, amine salt, calcium phosphate”both in Chinese and English. Literatures concerning antibacterial agents and antimicrobial composite resin were included, and repetitive research was excluded. RESULTS AND CONCLUSION：Antibacterial agents are classified into natural, organic, inorganic, polymer agents. Currently, antimicrobial composite resins carrying nano sliver, amine salt, and calcium phosphate are often reported. The vivo and vitro experiments show that the composite resin with antibacterial agents has good antibacterial properties, which can inhibit the growth of bacteria, reduce the occurrence of recurrent caries, and prolong the in-service life of the prosthesis, and its physical and chemical properties have no apparent changes. In the latest study, the composite resin has better antibacterial properties and mechanical functions by addition with al kinds of antibacterial agents, which wil be the main direction of studying the novel antimicrobial composite resin in the future.

关 键 词：生物材料 生物材料综述 复合树脂 抗菌剂 纳米 银离子 季胺盐 磷酸钙 综述 省级基金 

分 类 号：R318[医药卫生—生物医学工程]