从胰岛细胞移植到胰腺干细胞移植,治愈糖尿病还有多远?  

From islet cell transplantation to pancreatic stem cell transplantation in the treatment of diabetes

作　　者：王洪[1] 李金成[2] 李政[3] 孙海峰[4] 殷慧[1] 

机构地区：[1]吉林大学第一医院二部内分泌科,吉林省长春市130031 [2]吉林大学基础医学院,吉林省长春市130031 [3]吉林大学化学院,吉林省长春市130031 [4]吉林大学第二医院放射线科,吉林省长春市130031

出　　处：《中国组织工程研究》2013年第18期3389-3396,共8页Chinese Journal of Tissue Engineering Research

摘　　要：背景:胰岛细胞移植和胰腺干细胞移植是近年来糖尿病治疗的研究热点,也是治愈糖尿病最有希望的途径。目的:探讨胰岛细胞移植和胰腺干细胞移植治疗糖尿病的可行性、优势、面临的问题及解决的办法。方法:收集胰岛细胞移植和胰腺干细胞移植治疗糖尿病的相关实验和临床研究,进行实验数据分析两种细胞移植途径治疗糖尿病的影响因素,从细胞分子生物学水平认识胰岛细胞移植和胰腺干细胞移植治疗糖尿病的优势和缺点。结果与结论:胰岛细胞移植治疗糖尿病受供体不足的制约,胰腺干细胞移植解决了胰岛细胞供体短缺的有效途径,但胰腺干细胞移植的研究还停留在动物实验阶段,需要进行广泛的临床研究。首先要明确胰腺干细胞的特异性标志物,其次要掌握将相关干细胞诱导分化为胰腺干细胞的方法和技术。BACKGROUND： Islet cell transplantation and pancreatic stem cell transplantation are the research focus in the treatment of diabetes, and they are the most promising approaches. OBJECTIVE： To explore the feasibility, advantages, problems and solution methods of islet cell transplantation and pancreatic stem cell transplantation in the treatment of diabetes. METHODS： Relative experiments and clinical researches on islet cell transplantation and pancreatic stem ce transplantation for the treatment of diabetes were collected to analyze the experimental data. The influencing factors of islet cell transplantation and pancreatic stem cell transplantation in the treatment of diabetes were analyzed, and the advantages and disadvantages of islet cell transplantation and pancreatic stem cell transplantation in the treatment of diabetes were studied from the cell levels and molecular biology. RESUTLS AND CONCLUSION： Islet cell transplantation for the treatment of diabetes is limited with donor shortage, while pancreatic stem cell transplantation can solve the donor shortage, but the research on pancreatic stem cell transplantation is limited in animal experiments. Extensive clinical study can be conducted on the basis of the identification of specific markers of pancreatic stem cells, as well as the methods and techniques that can induce the relative stem cells to differentiate into pancreatic stem cells.

关 键 词：器官移植 器官移植综述 细胞移植 胰岛细胞移植 胰腺干细胞移植 细胞再生 糖尿病 诱导分化 胰腺 Β细胞 自体移植 同种异体移植 免疫耐受 免疫抑制 免疫排斥反应 体外培养 

分 类 号：R318[医药卫生—生物医学工程]