瞬时波强技术对2型糖尿病早期患者左心室舒张功能的研究  

Assessement of left ventricular diastolic function in patients with early type 2 diabetes mellitus by wave intensity

作　　者：朱虹[1] 田新桥[1] 茹翱[1] 吴朝明[2] 张超[1] 杨琰[1] 周娟[1] 刘敏[1] 郑磊[1] 

机构地区：[1]温州医学院附属第二医院超声科,325027 [2]温州医学院附属第二医院内分泌科,325027

出　　处：《中华超声影像学杂志》2013年第5期379-382,共4页Chinese Journal of Ultrasonography

基　　金：浙江省中医药科学研究基金项目（2010ZB096）;台州市科技局科研基金项目（1201ky31）

摘　　要：目的应用瞬时波强（WI）技术结合多普勒组织成像（DTI）分析2型糖尿病早期患者左室舒张功能变化。方法选择左室射血分数（LVEF）〉50％的单纯2型糖尿病（T2DM）患者21例和糖尿病合并高血压（T2DM＋EH）患者25例，正常对照组25例。应用脉冲多普勒测量舒张早期和舒张晚期二尖瓣口血流峰值速度（E、A），DTI测量二尖瓣环舒张早期和舒张晚期峰值速度（Ea、Aa），WI检测右颈总动脉瞬时减速度波强（W2），对比分析三组受试者各项指标的差异。结果与对照组比较，T2DM组Ea减低（P〈0．05），E／Ea呈增高趋势，但差异无统计学意义（P〉0．05），W2明显增高（P〈0.01）。T2DM＋EH组与对照组比较Ea明显减低（P〈0．01），E／Ea明显增高（P〈0．01），W2增高（P〈0．05）。与T2DM组比较，T2DM＋EH组E／Ea增高（P〈0．05），Ea、W2呈减低趋势，但差异无统计学意义（P〉0．05）。T2DM＋EH组、T2DM组与对照组比较，Aa呈增高趋势，但差异均无统计学意义（P〉0．05）。结论wI技术联合DTI可以无创、全面地评价2型糖尿病早期左室舒张功能异常改变。Objective To assess the left ventricular diastolic function in patients with early type 2 diabetes mellitus（T2DM） and combined with hypertension by using wave intensity（WI） and Doppler tissue imaging（DTI）. Methods 21 patients with T2DM and 25 T2DM patients with essential hypertension group （T2DM ＋ EH）,all of which had left ventricular ejection fraction （I.VEF） more than 50%, were enrolled in this study, and 25 healthy volunteers were taken as control group. Each patient underwent conventional echocardiography,DTI and WI exam. Peak velocities of early （E） and late （A） mitral inflow, peak early （Ea） and late （Aa） diastolic velocities of mitral annulus, E/Ea, and deceleration wave intensity （W2） of right common carotid artery（CCA） in three groups were measured and compared. Results Compared with the control group,W2 in T2DM group increased significantly （ P 〈0. 01） ,Ea was reduced （ P〈0.05） ,and E/Ea was significantly increased （ P 〈0.01）,Ea was significantly reduced （ P 〈0.01） and W2 increased significantly（ P 〈0.05） in T2DM ＋ EH group. Compared with the T2DM group, E/Ea in T2DM ＋ EH group was increased （P 〈0.05）, while W2 and Ea in T2DM ＋ EH group reduced, but no statistically significant differences were found. Conclusions WI combined with DTI may offer a new rapid method in noninvasive and comprehensive evaluation of left ventricular diastolic dysfunction in patients with T2DM and T2DM combined with EH.

关 键 词：超声心动描记术 糖尿病 2型 高血压 心室功能 左 

分 类 号：R54[医药卫生—心血管疾病] R587[医药卫生—内科学]