呋布西林钠合成工艺研究  

Study on Synthesis Technology of Furbenicillin Sodium

作　　者：郭剑虹 李祖文 周改平 

机构地区：[1]山西博康药业有限公司,太原030021

出　　处：《太原理工大学学报》2013年第3期298-301,共4页Journal of Taiyuan University of Technology

摘　　要：以6-氨基青霉烷酸(6-APA)和α-呋喃酰脲基苯乙酸钠为主要原料,经过酸酐化、缩合反应、萃取结晶制备呋布西林酸晶体,再与碳酸氢钠在水溶液中反应后,真空冷冻干燥制得呋布西林钠。考察了物料配比、反应温度、反应时间及萃取剂用量等因素对收率的影响,并通过正交试验对反应条件进行优化。在优化条件下,目标产物的总收率可达78.5%。产品经高效液相色谱分析,纯度达92.6%。Furbenicillin acid was prepared with 6-aminopenicillanic acid and α-[[[（2-furanylcarbonyl）amino]carbonyl]amino] benzeneacetic acid as material by anhydride reaction,condensation reaction,extraction and crystallization.Furbenicillin sodium was synthesized from furbenicillin acid by salting with sodium bicarbonate and then through freeze-drying.The effects of the ratio of raw material,reaction temperature,reaction time and amount of extractant on the yields of furbenicillin were investigated.The optimum reaction conditions were obtained by using orthogonal experimental design.Overall yield was 78.5% under the conditions and the product was analyzed by HPLC,the purity reached 92.6%.

关 键 词：6-APA 合成 萃取 正交试验 呋布西林钠 

分 类 号：TQ465.1[化学工程—制药化工]