^(11)C-乙酸盐自动化合成改进工艺及PET/CT显像  

Improved Automated Synthesis and Preliminary Animal PET/CT Imaging of ^(11)C-acetate

作　　者：甘满权[1] 唐小兰[2] 唐刚华[3] 王红亮[3] 胡孔珍[3] 

机构地区：[1]广州医学院第一附属医院PET/CT中心,广州510230 [2]华南农业大学理学院,广州510642 [3]中山大学附属第一医院核医学科,广州510515

出　　处：《同位素》2013年第2期73-78,共6页Journal of Isotopes

基　　金：国家高科技计划(863计划)专题课题(2008AA02Z430);国家自然科学基金面上项目(30970856);广东省科技计划项目(2010B031600054);广州市科技计划重点项目(11S72060016)

摘　　要：采用国产碳-11胆碱/蛋氨酸自动合成模块,研究简单、快速、自动化合成11 C-乙酸盐(11 C-AC)的工艺流程。11 C-CO2与溴化甲基镁(MeMgBr)在改进的Loop环内反应生成中间体乙酰溴化镁加合物,中间体经在柱水解和SEP-PAK小柱纯化后制备11 C-AC注射液。总合成时间约8min,校正放化产率为(40.5±4.6)%,放化纯度大于95%。该改进法适于多种商用全自动化模块自动化生产11 C-AC。生产的11 C-AC注射液安全、有效,有望用于动物和人体PET显像研究。To study a simple and rapid automated synthetic technology of 11C-acetate （11 C- AC）, automated synthesis of lie-at was performed by carboxylation of MeMgBr/tetra- hydrofuran （THF） on a polyethylene loop with 11C-C（）2, followed by hydrolysis and purifi- cation on solid-phase extraction cartridges using a 11C-Choline/Methionine synthesizer made in China. A high and reproducible radiochemical yield of above 40% （decay corrected） was obtained within the whole synthesis time about 8 rain from i1 C-CO2. The radiochemical pu- rity of 11C-AC was over 950/oo. The novel, simple and rapid on-column hydrolysis-purifica- tion procedure should adaptable to the fully automated synthesis of 11C-AC at several com- mercial synthesis module.

关 键 词：11C-乙酸盐 PET显像剂 自动化合成 

分 类 号：R817.4[医药卫生—影像医学与核医学] O621.25[医药卫生—放射医学]