不同病因的肺动脉高压患者肺动脉压力水平研究  

Comparison of Pulmonary Artery Pressure Levels in Patients with Pulmonary Hypertension of Different Causes

作　　者：郭璐[1] 刘跃建[1] 解郑良[1] 周仲伟[1] 杨阳[1] 陈庆[1] 邹俊[1] 

机构地区：[1]四川省医学科学院.四川省人民医院呼吸内科,四川省成都市610072

出　　处：《中国全科医学》2013年第13期1487-1489,1492,共4页Chinese General Practice

基　　金：四川省卫生厅科研项目(090442)

摘　　要：目的研究不同病因的肺动脉高压(PH)患者肺动脉压力水平。方法对2006年1月—2010年12月五年间四川省人民医院门急诊及住院部诊断符合PH的2 240例患者进行回顾性分析,比较不同病因PH患者的肺动脉收缩压(PASP)水平。结果 2 240例患者中,PASP水平为轻、中、重度的分别占43.79%(981/2 240)、37.41%(838/2 240)和18.80%(421/2 240)。动脉性PH、左心疾病相关性PH、呼吸系统疾病和(或)缺氧相关性PH、慢性血栓栓塞性PH、未明确的多种因素所致PH的PASP平均值分别为(60±19)mm Hg、(52±17)mm Hg、(50±13)mm Hg、(61±13)mm Hg和(56±14)mm Hg,经方差分析差异有统计学意义(P<0.05)。PASP水平最高的前3类亚型分别为新生儿持续肺高压(97±6)mm Hg、先天性心脏病相关性PH(72±28)mm Hg和特发性PH(67±14)mm Hg,与其他亚型相比差异均有统计学意义(P<0.05);PASP水平最低的亚型为门静脉高压相关性PH(35±15)mm Hg和睡眠呼吸障碍相关性PH(35±16)mm Hg,与其他亚型相比差异均有统计学意义(P<0.05)。结论 PH患者的肺动脉压力水平多为轻～中度。压力最高的PH亚型是新生儿持续性肺高压、先天性心脏病相关性PH和特发性PH,对以上类型PH的患者尤其需要重视。Objective To analyze and compare the levels of pulmonary artery pressure due to different causes in pa- tients with pulmonary hypertension （PH） . Methods The data of 2 240 patients diagnosed with PH were retrospectively analyzed from outpatient department, emergency center and inpatient department of Sichuan provincial people＇s hospital from January 2006 to December 2010. The levels of pulmonary artery systolic pressure （PASP） were analyzed and compared for these patients with different causes. Results The proportion of mild, moderate and severe degree of PASP among the 2 240 patients was 43.79% （981/2 240）, 37. 41% （838/2 240） and 18. 80% （421/2 240） respectively. The level of mean PASP in patients with PH due to pulmonary arterial hypertension, left heart disease, chronic lung disease and/or hypoxia, chronic thromboembolic pulmonary hypertension and miscellaneous factors were respectively （60 ± 19） mm Hg, （52 ± 17） mm Hg, （50 ± 13） mm Hg, （61 ± 13） mm Hg and （56 ±14） mm Hg, with a statistically significant difference by analysis of variance （P 〈0.05） . The top 3 subtypes of PH which possessed the highest level of PASP were persistent pulmonary hypertension of the newborn being （97 ± 6） mm Hg, pulmonary hypertension due to congenital heart diseases being （72 ± 28） mm Hg, and idiopathic pulmonary arterial hy- pertension being （67 ± 14） mm Hg respectively, with significant difference as compared with other subtypes （P 〈0. 05 ） . And the subtypes with lowest level of PASP were PH due to portal hypertension and sleep - disordered breathing, being respectively （35 ± 15） mm Hg and （35 ± 16） mm Hg, with significant difference as compared with other subtypes （P 〈0. 05）. Conclusion The degree of pulmonary artery pressure is generally mild to moderate in patients with pulmonary hypertension. The highest - leveled subtypes of PH are persistent pulmonary hypertension of the newborn, pulmonary hypertension due to congenital heart dis-

关 键 词：高血压 肺性 肺动脉压力 病因 特征 

分 类 号：R544.16[医药卫生—心血管疾病]