GIRK通道开放剂在癫痫大鼠中抗癫痫的研究  

The study on the anti-epilepsy effect of GIRK channel openers in epileptic rats

作　　者：吕华军 钟国栋[2] 

机构地区：[1]浙江省诸暨市第二人民医院内科,浙江诸暨311811 [2]浙江大学医学院附属第二医院脑电图室,浙江杭州310009

出　　处：《中国现代医生》2013年第16期10-11,15,共3页China Modern Doctor

基　　金：浙江省教育厅项目(Y201019019)

摘　　要：目的探讨GIRK通道开放剂氟吡汀(flupirtine)对癫痫大鼠癫痫发作和脑电图的影响。方法 30只雄性健康成年SD大鼠随机平均分成三组:正常对照组、癫痫+生理盐水(NS)组和癫痫+氟吡汀(flupirtine)组。癫痫+生理盐水(NS)组和癫痫+氟吡汀(flupirtine)组两组动物复制青霉素诱发癫痫模型,造模成功后分别给予生理盐水和氟吡汀治疗,再观察痫样行为和脑电图。结果正常对照组行为学和脑电图均正常;癫痫+生理盐水组有明显痫样行为,脑电图呈现明显的尖波、棘波、尖-慢复合波以及棘-慢复合波的阵发性痫样放电;癫痫+氟吡汀组大部分大鼠行为正常或是轻度的痫样行为,脑电图恢复正常的基础波放电,只有1例呈少量的痫样放电。结论 GIRK通道开放剂flupirtine对癫痫大鼠痫样行为和异常的脑电图有改善作用。Objective To study the anti-epilepsy effect of GIRK channel opener（flupirtine） on the EEG and epileptic behavior in epileptic rats. Methods Thirty healthy male adult SD rats were randomly divided into three groups： nor- mal control group, epileptie＋NS group, and epileptic＋ flupirtine group. Penicillin was injected to induced epilepsy in rats of epileptic＋NS group and epileptic＋ flupirtine group. Epileptic behavior and EEG were observed in all groups. Results Normal behavior and EEG were normal on normal control rats. Epileptic behavior and epileptic discharge in- cluding sharp, spike waves, sharp-slow wave complex and spike-slow wave complex in EEG were observed on the epileptie＋NS rats. Epileptic behavior and epileptic discharge in EEG were rare on the epileptic＋flupirtine rats. EEG showed normal based wave discharges. There was only 1 rat in epileptic-form discharges in epileptie＋flupirtine group. Conclusion GIRK channel opener （flupirtine） can markedly alleviate the severity of epileptic behavior and discharge in EEG in epileptic rats.

关 键 词：癫痫 GIRK通道 氟吡汀 大鼠 

分 类 号：R96[医药卫生—药理学]