妊娠期肝内胆汁淤积症孕妇胎盘床中HIF-1α的表达及临床意义  

Expression and its clinical significance of the placenta bed HIF-1 alpha in women with intrahepatic cholestasis during pregnancy

作　　者：裘琳[1] 吴翔燕[1] 范睿嘉[1] 

机构地区：[1]杭州师范大学附属医院妇产科,浙江杭州310015

出　　处：《中国现代医生》2013年第16期44-45,48,共3页China Modern Doctor

基　　金：浙江省杭州市卫生科技一般项目(2010A012)

摘　　要：目的探讨缺氧诱导因子HIF-1α在妊娠期肝内胆汁淤积症(ICP)患者胎盘床中的表达及临床意义。方法采用免疫组织化学SP法检测HIF-1α在22例正常妊娠胎盘床组织和21例ICP胎盘床组织中的表达。结果22例正常妊娠胎盘床组织HIF-1α阳性表达9例,总阳性率为40.91%,21例ICP胎盘床组织中HIF-1α阳性表达15例,总阳性率为71.43%,两组间差异有统计学意义(P<0.05)。结论 HIF-1α在ICP患者胎盘床组织中的高表达,从蛋白水平证实HIF-1α可能是ICP患者缺氧的一个敏感指标。Objective To study the oxygen factor HIF - 1 alpha in intrahepatic cholestasis during pregnancy （ICP） in patients with placental bed in the expression and clinical significance. Methods Using immunohistochemical SP method to detect HIF-1 alpha placental bed in 23 cases of normal pregnancy group and 21 cases of ICP placenta tis- sue expression of bed. Results A total of 22 cases of normal placental bed in pregnancy tissue HIF-1 alpha positive expression of 9 cases, total positive rate was 40.91%, 21 cases of ICP placenta tissue bed HIF-1 alpha positive ex- pression in 15 cases, the total positive rate was 71.43%, the difference between the two groups was statistically signif- icant （P 〈 0.05）. Conclusion HIF-1 alpha in the tissue of patients with ICP placenta bed high expression, from the level of protein alpha confirmed HIF-1 May be a sensitive indicator of ICP patients anoxia.

关 键 词：缺氧诱导因子HIF-1Α 妊娠期肝内胆汁淤积症 免疫组织化学 胎盘床 

分 类 号：R714.2[医药卫生—妇产科学]