盐酸坦索罗辛对慢性前列腺炎患者局部免疫功能的影响  

Study of tamsulosin hydrochloride intervention of local immune function of patients with chronic prostatitis

作　　者：许青河[1] 邵四海[2] 

机构地区：[1]浙江省湖州市中心医院药剂科,浙江湖州313000 [2]浙江省湖州市第一人民医院泌尿外科,浙江湖州313000

出　　处：《中国现代医生》2013年第16期72-73,80,共3页China Modern Doctor

基　　金：浙江省医药卫生科技计划(2012KYB199)

摘　　要：目的研究盐酸坦索罗辛对慢性前列腺炎患者局部免疫功能的影响。方法 60例慢性前列腺炎患者随机分为观察组和对照组。对照组采用抗生素治疗;观察组在对照组用药方式的基础上,加用盐酸坦索罗辛缓释胶囊。结果治疗6周后,观察组总有效率86.67%高于对照组总有效率60.00%,差异有统计学意义(P<0.05)。两组治疗后比较,观察组患者的前列腺液白细胞数降低较对照组明显(P<0.05)。治疗6周后,观察组患者的前列腺液中SIgA水平较对照组下降明显,差异有统计学意义(P<0.01)。结论盐酸坦索罗辛可明显改善慢性前列腺炎患者的前列腺液中SIgA水平,并可能对前列腺局部的免疫功能具有调节作用。Objective To study of tamsulosin hydrochloride intervention of local immune function of patients with chronic prostatitis. Methods Sixty cases of chronic prostatitis patients were divided into the observation group and the control group. The control group： treated with antibiotic. The observation group： Based on the treatment methods of the control group, plus： tamsulosin hydrochloride sustained release capsules. Results After 6 weeks of treatment, the total efficiency of the observation group was 86.67% was higher than the control group （60.00%）, there were signif- icant differences（P 〈 0.05）. The two groups after treatment, prostate fluid white blood cell count decreased of the ob- servation group were more obvious than those in the control group （P 〈 0.05）. After 6 weeks of treatment, the level of SIgA in prostatic fluid drop more,patients in the observation group, compared with the control group, there were sig- nificant differences （P 〈 0.01 ）. Conclusion Tamsulosin hydrochloride can significantly improve the level of SIgA in prostatic fluid of patients with chronic prostatitis, and may play a role in the regulation of the prostate about the local immune function.

关 键 词：盐酸坦索罗辛 慢性前列腺炎 抗生素 前列腺液 白细胞数 分泌型免疫球蛋白A 

分 类 号：R697.33[医药卫生—泌尿科学]