两种不同方法治疗成人支气管哮喘急性发作的临床疗效比较  

The comparision of the clinical efficacy of two kinds of methods for management of acute exacerbation of bronchial asthma in aldults

作　　者：陈瑞芳[1] 曾育辉[1] 梁秋玲[1] 

机构地区：[1]广东药学院附属第一医院急诊科,广东广州510080

出　　处：《中国现代医生》2013年第16期140-142,共3页China Modern Doctor

摘　　要：目的观察和比较两种不同方法治疗成人支气管哮喘中度急性发作的临床疗效。方法 80例哮喘中度急性发作患者随机分成A、B两组各40例。A组给予定量雾化吸入布地奈德混悬液6 mg/d和孟鲁司特10 mg1次/d口服;B组给予30 mg强的松片每日顿服。两组患者均每日雾化吸入可必特液2.5 mL/次,2次/d,共治疗7 d,比较两组患者的临床治疗效果。结果①A组治疗后总有效率95%;B组治疗后总有效率80%。A组总有效率高于B组,差异有统计学意义(P<0.05);②A组临床症状、体征缓解的时间均明显短于B组,差异有统计学意义(P<0.05);③两组治疗期间未见明显不良反应。结论雾化吸入布地奈德混悬液(BIS)联合孟鲁司特口服治疗成人支气管哮喘中度急性发作效果更好,值得临床推广应用。Objective To observe and compare the two different methods for treatment of adult asthma in acute attack. Methods Eighty patients with moderate asthma acute attack were randomly divided into A, B two groups of 40 cases. In group A, treated with quantitative inhalation of budesonide suspension in 6 mg/d and Monrus Te lOmg 1 times a day orally; B group was treated with prednisone 30 mg once a day. Two groups of patients were daily nebulized in- halation of combivent solution 2.5 mL/time, 2 times/D, a total of 7 days treatment, compared two groups of patients with clinical curative effect. Results （1）A group after treatment, the total effective rate was 95%; B group after treat- ment, the total effective rate was 80%. The total effective rate of A group was higher than that of B group, the differ- ence was statistically significant （P 〈 0.（）5）;（2）A group of clinical symptoms, signs of the time were significantly short- er in the B group, the difference was statistically significant （P 〈 0.05） ; （3）Two groups had no obvious adverse reaction. Conclusion Inhalation of budesonide suspension （BIS） combined with oral montelukast in treatment of adult asthma in acute attack effect is better, is worthy of clinical application.

关 键 词：支气管哮喘 布地奈德 孟鲁斯特 雾化吸入 强的松 急性发作 

分 类 号：R562.2[医药卫生—呼吸系统]