阿托伐他汀治疗对比剂肾病的疗效观察  

Efficacy of Atorvastatin Treatment of CIN

作　　者：王金会[1] 李琳[1] 赵慧娟[1] 冯静波[1] 赵培勇[1] 

机构地区：[1]威海市立医院心内科,山东威海264200

出　　处：《中国医药指南》2013年第10期429-430,共2页Guide of China Medicine

摘　　要：目的探讨水化加阿托伐他汀时患者PCI术后肾损伤的保护作用及预防对比剂肾病的效果。方法选择冠心痛患者65倒,随机分为2组:对照组30例(常规水化),实验组35例(阿托伐他汀+常规水化)。于PCI术前、术后72 h、造影后第7天分别测定血肌酐、血素氮水平。结果实验组与对照组比较,实验组患者PCI术后72 h及造影后第7天血肌酐、血尿素明显降低,差异有统计学意义(P<0.05)。实验组患者对比剂肾病2倒,发生率为5.9%对照组对比剂肾病3例,发生率为11.5%,实验组对比剂肾病发生率明显低于对照组,差异有统计学意义(P<0.05)。结论在水化基础上,PCI术前使用阿托伐他汀可明显改善老年患者术后的肾脏功能,明显降低对比剂肾病的发生率。Objective Explore is hydration of Jia Atuo cutting statins after PCI in patients with renal injury in rats and the effect of prevention of contrast- induced nephropathy. Methods Coronary heart patients 65 cases were randomly divided into 2 groups： control group of 30 patients （conventional hydration）, the experimental group of 35 patients （atorvastatin ＋ conventional hydration）. Before PCI, after 72 h, the 7th day after angiography were measured in serum creatinine, blood urea nitrogen levels. Result The experimental group compared with control group, the experimental group patients after PCI, 72 h and 7 days after contrast serum creatinine, blood urea significantly reduced, the difference was statistically significant （P〈0.05）. Experimental group patients with CIN 2 down, the incidence of CIN 3 cases of 5.9% in the control group, the incidence of 11.5%, the experimental group of CIN was significantly lower than the control group, the difference was statistically significant （P〈0.05）. Conclusion On the basis of hydration, PCI preoperative atorvastatin can significantly improve renal function in elderly patients, significantly reduced the incidence of contrast-induced nephropathy.

关 键 词：肾病 肌酐 尿素氮 肾功能不全 阿托伐他汀 

分 类 号：R692.3[医药卫生—泌尿科学]