心肌血流灌注断层定量显像在犬急性心肌梗塞疗效评价中的应用  

Application of myocedal perfasion quantitative imaging for the evaluation of therapeutic effect in canine with myocardial infarction

作　　者：梁宏[1] 陈炬[2] 刘生[2] 曾世荃[1] 

机构地区：[1]中山医科大学附属第一医院,广州510080 [2]中山医科大学孙逸仙纪念医院,广州510080

出　　处：《核技术》2000年第5期308-311,共4页Nuclear Techniques

基　　金：广东省自然科学基金!950338

摘　　要：在１０只犬的实验性心肌梗塞模型上进行心肌断层显像与容积定量分析，对照病理解剖资料评价主要定量参数心肌缺损体积（ＤＶ）及缺损范围分数（ＤＦ）的准确性；另２１只犬分为对照组和Ｎｄ：ＹＡＧ激光心肌血管重建术（ＴＭＲ）组；分别进行实验性心肌梗塞术后心肌断层定量显像。结果表明：病理解剖定量分析获得的心肌梗塞区体积（ＩＶ）与心肌血流断层定量结果ＤＶ值具有良好相关（ｒ＝０．８８），两种方法所计算的心肌病变范围分数（ＤＦ）无显著性差异（Ｐ＞０．０５）。ＴＭＲ组实验犬其ＤＦ值明显小于心梗对照组（Ｐ＜０．０５），分别为２７．５％± ３．９％和３２．１％±４．６％。结果提示：^（９９ｍ）Ｔｃ－ＭＩＢＩ心肌断层定量显像能较准确地判断心肌血流及病变范围，是一种较好的冠心病诊断及疗效评价方法，Ｎｄ：ＹＡＧ　ＴＭＲ治疗具有改善缺血心肌血流灌注及缩小心肌梗塞范围的作用。Myocardial blood perfusion (MBP) ECT and quantitative analysis were performed in 10 canines with experimental acute myocardial infarct(AMI). The accuracy of main myocardial quantitative index, including defect volume(DV) and defect fraction(DF), was estimated and correlated with histchemical staining (HS) of infarcted area. Other 21/AMI canines were divided into Nd:YAG laser tyansmyocardial revascularization treated group LTMR and control group. All canines were performed MBP ECT after experimental AMI. Results found that the infarcted volume (IV) measured by HS has well correlated (r=0.88) with DV estimated by myocardial quantitative analysis. But the DF values calculated by both methods was not significantly different (t= 1.28 P>0.05). In LTMR group 27.5% ± 3.9%, the DF is smaller than control group 32.1% ± 4.6% (t = 2.49 P<0.05). Results indicate that ^(99m)Tc-MIBI myocardial perfusion SPECT and quantitative study can accurately predict the myocardial blood flow and magnitude of injured myocardium. Nd:YAG LTMR could improve myocardial blood perfusion of ischemic myocardium and decrease effectively the infarct areas.

关 键 词：心肌梗塞 放射性核素显像 激光心肌血管重建术 

分 类 号：R817.42[医药卫生—影像医学与核医学]