辛酸─1—^(13)C的合成与分析  

The synthesis and analysis of octanoic-1-^(13)C acid

作　　者：王惠琼[1] 赵夏令[1] 唐国忠[1] 

机构地区：[1]中国科学院上海原子核研究所,上海201800

出　　处：《核技术》2000年第2期136-141,共6页Nuclear Techniques

摘　　要：将以溴代正庚烷为原料合成的格氏试剂溴化正庚基镁与Ｂａ１３ＣＯ３和浓Ｈ２ＳＯ４作用产生的１３ＣＯ２进行羧化反应，通过水解，提纯，制得辛酸─１─１３Ｃ，产率可达９０％─９３％。用薄层层析对其进行了定性分析，利用ＭＳ、ＩＲ、１Ｈ－ＮＭＲ和１３Ｃ－ＮＭＲ对其进行了结构分析和测定１３Ｃ丰度（８９．５％），并按口服药物的质量要求，用ＩＣＰ－ＡＥＳ和ＡＦＳ方法对有关金属元素进行了定量测定。A Grignard reagent prepared from n-heptyl bromide was carbonated with the carbon-1-^(13)C dioxide liberated from barium carbonate-1-^(13)C and concentrated sulfuric acid. The octanoic-1-^(13)C acid was obtained by acidic hydrolysis and purified by extraction. The yield was more than 90%. To analyze the structure and compute the ^(13)C abundance of the octanoic-1-^(13)C acid, various analysis of MS, IR, ~1H-NMR and ^(13)C-NMR were performed. According to the quality demand of the oral drug, the quantitative measurements of some metallic elements had also been carried out.

关 键 词：辛酸 碳-13 合成 分析 标记化合物 诊断试剂 

分 类 号：R817.4[医药卫生—影像医学与核医学]