抗中性粒细胞胞质抗体相关性系统性血管炎周围神经损伤临床与神经传导检测  

An analysis of clinical manifestations and nerve damage in ANCA-associated systemic vasculitis

作　　者：彭子娟[1] 包正军[1] 曾国华[1] 朱勇[1] 卢瑛[2] 

机构地区：[1]湖南省株洲市一医院神经内科,湖南株洲412000 [2]湖南省株洲市一医院肾内科,湖南株洲412000

出　　处：《癫痫与神经电生理学杂志》2013年第3期164-166,共3页Journal of Epileptology and Electroneurophysiology(China)

摘　　要：目的：探讨抗中性粒细胞胞质抗体（ANCA）相关系统性血管炎（AAsV）周围神经损伤的临床和神经传导检测（NCS）的特征。方法：回顾性分析AASV伴周围神经损伤5例患者临床表现及NCS结果。结果：5例AASV伴周围神经损伤患者中，2例表现为双侧对称性多神经病，1例表现为神经根丛病，2例表现为不对称的多数性单神经病，并可以周围神经病起病，感觉运动神经均受累，感觉神经症状出现较早，且刺激症状突出。电生理检查发现感觉或运动神经传导以波幅显著降低为主，下肢感觉神经受累明显。结论：AASV可累及周围神经系统，对不明原因的周围神经损伤，或多系统受累的患者需考虑AASV可能。Objective： To explore the clinical manifestations and nerve conduction study（NCS） of peripheral nerve damage in ANCA-associated systemic vasculitis（AASV）. Methods：The clinical manifestations and nerve conduction in five patients with peripheral neuropathy in AASV were analyzed retro- spectively. Results：Of the 5 patients with peripheral neuropathy, 2 had symmetric polyneuropathy,1 had sciatica and 2 had asymmetric multiple mononeuropathy. The initial symptom of 1 patient showed peripheral neuropathy. The sensory symptoms occurred early and the sensory nerves were predominated,especially showing the irritating symptoms. Amplitudes of sensory and motor nerves markedly decreased or got absent according to electrophysiology. The lower limbs were involved earlier and more severely. Conclusion：Peripheral nervous systems can be involved in AASV . It should be considered as the cause for peripheral neuropathy and the cause for unknown ＇wultiple system damage.

关 键 词：抗中性粒细胞胞质抗体(ANCA) ANCA-系统性相关性血管炎(AASV) 周围神经病 神经传导检测(NCS) 

分 类 号：R543[医药卫生—心血管疾病] R741.044[医药卫生—内科学]