不同剂量阿托伐他汀对扩张型心肌病患者外周血内皮微粒及内皮祖细胞的影响比较  

Comparison of the effects of 10 and 40 milligram doses of atorvastatin on circulating endothelial-derived microparticles and endothelial progenitor cells in patients with dilated cardiomyopathy

作　　者：卓裕丰[1,2] 许顶立[1,2] 程颖[2] 黄冰生[1,2] 解强[2] 林桂雄[2] 

机构地区：[1]南方医科大学南方医院心血管内科,广州市510515 [2]广州市番禺区何贤纪念医院心血管内科,511400

出　　处：《实用医学杂志》2013年第11期1759-1761,共3页The Journal of Practical Medicine

基　　金：广东省广州市卫生系统一般引导项目(编号:2009-YB-186)

摘　　要：目的:比较不同剂量阿托伐他汀对扩张型心肌病患者外周血内皮微颗粒(circulating endothelial-derived microparticles,cEMPs)及内皮祖细胞(circulating endothelial progenitor cells,cEPCs)的影响。方法:确诊为扩张型心肌病的患者70例,均给予阿托伐他汀治疗,随机分为10 mg组(n=35)及40 mg组(n=35)。研究前及治疗1年后检测cEMPs及cEPCs。结果:结束时,与10 mg组比较,40 mg组cEMPs显著降低(P<0.05),cEPCs显著升高(P<0.05)。cEMPs变化值与cEPCs变化值呈负相关。结论 :40 mg阿托伐他汀能够更显著地降低扩张型心肌病患者cEMPs及升高cEPCs。Objective To investigate the differences of 40 mg and 10 mg atorvastatin on circulating endothelial-derived microparticles （eEMPs） and circulating endothelial progenitor cells （cEPCs） in patients with dilated cardiomyopathy （DCM）. Methods Seventy patients with DCM were enrolled into this study, and randomly assigned to 10 mg group （n = 35） and 40 mg group （n = 35）. The levels of eEPCs and cEMPs were examined at baseline and after one year. Results At dose of 40 rag, the levels of cEMPs significantly decreased, whereas the levels of cEPCs significantly increased in comparison with 10-mg dose （P 〈 0.05 ）. Linear correlation analysis showed significant inverse relationship between the change of eEMPs and cEPCs. Conclusions 40 mg atorvastatin might decrease the levels of cEMPs and increase the numbers of cEPCs in patients with DCM obviously.

关 键 词：心肌病 扩张型 他汀 内皮祖细胞 内皮微颗粒 

分 类 号：R614[医药卫生—麻醉学]