酸枣仁镇静催眠活性部位的筛选  

Screening of Sedative-hypnotic Active Fraction of Ziziphus jujuba

作　　者：崔思娇[1] 贾英[1] 罗洁[1] 石绍淮[1] 范旭航[1] 毕开顺[2] 

机构地区：[1]沈阳药科大学中药学院,沈阳110016 [2]沈阳药科大学药学院,沈阳110016

出　　处：《中国药房》2013年第23期2128-2129,共2页China Pharmacy

基　　金：辽宁省科学技术计划立项资助课题(No.2011412004);辽宁省教育厅高等学校科研资助项目(No.2009T097)

摘　　要：目的:筛选酸枣仁镇静催眠作用的活性部位。方法:采用注射阈下剂量和阈上剂量戊巴比妥钠,比较高、低剂量酸枣仁总提取物和不同极性部位(10、5g/kg)对模型小鼠入睡率、入睡潜伏期与持续睡眠时间的影响。结果:高剂量酸枣仁乙酸乙酯提取物、高、低剂量酸枣仁正丁醇提取物与高、低剂量酸枣仁总提物可使模型小鼠入睡率显著增加,睡眠潜伏期显著延长(P<0.01或P<0.05);高、低剂量酸枣仁乙酸乙酯提取物,高、低剂量酸枣仁正丁醇提取物与高、低剂量酸枣仁总提物可使模型小鼠睡眠时间显著延长(P<0.01)。结论:酸枣仁乙酸乙酯部位和正丁醇部位是酸枣仁镇静催眠活性部位。OBJECTIVE： To screen the sedation-hypnotic active fraction of Ziziphus Jujuba. METHODS： By injecting sub-threshold dose and suprathreshold dose of pentobarbital sodium, comparing effective of Z. Jujuba extract and different polar parts on the sleep rates , the sleep latency and duration of sleep in model mice.RESULTS： The high dose of semen Z. jujuba ethyl acetate extract, high, low dose of semen Z. jujuba n-butanol extract and high, low dose of semen Z. jujubg total extract can make sleep model mice was significantly increased, sleep latency was significantly prolonged （P〈0.01 or P〈0.05） ; high, low dose of semen Z. jujuba acetic acid ethyl ester extract, high, low dose of Z. jujuba n-butanol extract and high, low dose total extract of semen Z. jujuba can make the time to sleep in mice model was significantly prolonged（P〈0.01）. CONCLUSIONS： Z. jujuba acetic acid eth-yl ester and n-butanol is Z. jujuba sedative and hypnotic active site.

关 键 词：酸枣仁 镇静 催眠 活性部位 

分 类 号：R285.5[医药卫生—中药学] R284[医药卫生—中医学]