自拟活血益肺化瘀中药煎剂联用血府逐瘀散对肺动脉高压模型大鼠肺血管重构的影响  

Effects of Self-precsribed Activating Blood,Tonifying Lung and Removing Blood Stasis Decoction Combined with Xuefu Zhuyu Powder on Pulmonary Vascular Remodeling in PH Rats

作　　者：陈晓北[1] 

机构地区：[1]赤峰学院医学院,内蒙古赤峰024000

出　　处：《中国药房》2013年第23期2135-2137,共3页China Pharmacy

摘　　要：目的:研究自拟活血益肺化瘀中药煎剂联用血府逐瘀散对肺动脉高压模型大鼠肺血管重构的影响。方法:通过皮下注射野百合碱以复制大鼠肺动脉高压模型。实验分为空白对照(等容生理盐水)、模型(等容生理盐水)、自拟活血益肺化瘀中药煎剂(2mg/kg)、血府逐瘀散(2mg/kg)、自拟活血益肺化瘀中药煎剂+血府逐瘀散(2mg/kg+2mg/kg)组,灌胃给药,每天1次,连续28d。多参数监护仪测定大鼠平均肺动脉压(mPAP),检测右心室肥大程度[右心室(RV)(/左心室+空间隔,LV+S)质量比值],以平滑肌-α-肌动蛋白(SM-α-actin)染色计算无肌性小动脉肌化程度,测定大鼠肺小动脉血管壁厚度百分比(WT%)。结果:与模型组比较,各用药组大鼠mPAP、RV(/LV+S)、WT%和肺无肌性小动脉肌化程度显著减轻(P<0.05)。结论:自拟活血益肺化瘀中药煎剂联用血府逐瘀散对肺动脉高压肺血管重构具有协同效应。OBJECTIVE： To study the effects of self-prescribed activating blood, tonifying lung and removing blood stasis （SABTLRBS） decoction combined with Xuefu zhuyu powder on pulmonary vascular remodeling in PAH rats. METHODS： PAH model was induced by hypodermic injection of monocrotaline. Model rats were divided into blank control group（constant volume of normal saline）, model group （constant volume of normal saline）, SABTLRBS decoction group （2 mg/kg）, Xuefu zhuyn powder group（2 mg/kg）, drug combination group（2 mg/kg＋2 mg/kg）. They were given medicines once a day for consecutive 28 days. Multi-parameter monitor to measure the mean pulmonary arterial pressure （mPAP）, detection of degree of right ventricular hypertro- phy, with smooth muscle-actin（SM-a-actin） were calculated without muscular muscle degree, determination of pulmonary arteriole wall thickness （WT%） of rats. RESULTS： Compared with model group, mPAP, right ventricle hypertrophy index[RV/（LV＋S）], percentage of vessel wall thickness （WT%） and muscularizing of non-muscular artery in the medicine groups relieved significantly （P〈0.05）. CONCLUSIONS： It indicats that SABTLRBS decoction combined with Xuefu zhuyu powder have synergistic effect on pulmonary vascular remodeling.

关 键 词：肺动脉高压 血管重构 自拟活血益肺化瘀中药煎剂 血府逐瘀散 联合 

分 类 号：R97[医药卫生—药品] R285[医药卫生—药学]