氟喹诺酮类抗菌药物耐药性与耐药机制的研究进展  

Recent Advances in Evaluation of Resistance Epidemiology and Mechanisms of Fluoroquinolone

作　　者：罗景慧[1] 刘永刚[2] 杨西晓[1] 候连兵[1] 杨迎暴[3] 

机构地区：[1]南方医院药学部,广州510515 [2]武警广东总队医院药剂科,广州510507 [3]南方医科大学药学院临床药理研究室,广州510515

出　　处：《抗感染药学》2013年第2期86-91,共6页Anti-infection Pharmacy

摘　　要：目前,喹诺酮类药物(fluoroquinolones,FQs)是临床最常用的人工合成抗菌药物;但是,在抗菌药的选择压力下,临床常见致病菌对FQs耐药问题日渐严重。利用PubMed和CNKI两大数据库平台,检索2011—2012年期间发表的FQs耐药流行病学、耐药机制和有效对策的文献,对其研究进展作一综述,并对有效防控FQs耐药性提出相应对策措施。Fluoroquinolones（FQs）are the most widely used synthetic antibacterial drugs in the clinical. However, FQs have been acquiring more and more resistance in the common pathogens in the clinical practice because of the selective pressure. Based on two large data bases, PubMed and CNKI, the research literatures involving the advances of FQs-resistant epidemiology, mechanisms and anti-resistance strategies published between 2011 and 2012 were retrieved and reviewed. In the meantime, and the effective procedures to prevent FQs resistance were discussed.

关 键 词：氟喹诺酮类 耐药性 耐药机制 

分 类 号：R917[医药卫生—药物分析学]