关节置换术后感染的药物治疗  

Medication for Infection after Joint Replacement

作　　者：柏青[1] 尹丽芳[1] 耿立坚[1] 

机构地区：[1]武汉科技大学附属天佑医院,武汉430064

出　　处：《抗感染药学》2013年第2期125-127,共3页Anti-infection Pharmacy

摘　　要：髋和膝等关节置换术后的人工关节感染6个月内发生率较高,其致病菌主要为凝固酶阴性葡萄球菌、金葡菌、链球菌属、革兰阴性杆菌、厌氧菌等,多采用以静脉或口服高生物利用度的抗感染药物或联合治疗以控制其感染的治疗方案。综述国内外近年来在关节置换术后控制感染的药物治疗的研究进展文献,并对其作了分析与论述。There is highest rate of prosthetic joint infection（PJl） within six months of hip and knee joint replacement, the primary pathogenic bacteria are coagulase negative Staphylococcus, Staphylococcus aureus, Streptococcus, Gram-negative bacteria and anaerobe, etc.. The management of PJI almost always necessitates the need for surgical inter- vention and prolonged courses of intravenous or oral antimicrobial therapy. The author reviews the intravenous or highly bioavailable oral antimicrobial treatment of common microorganisms causing prosthetic joint infection and common antimicrobials used for chronic oral antimicrobial suppression.

关 键 词：人工关节感染 抗感染药物 治疗方案 

分 类 号：R969.3[医药卫生—药理学]