参附注射液对脓毒症肝损伤疗效的临床研究  

Clinical study of clinical efficacy of shenfu injection on sepsis after liver injury

作　　者：陈昊 乔丽旻 张莉芬[3] 李俊[3] 王毅[3] 奚希相[3] 朱杰[3] 周超 

机构地区：[1]上海市浦东新区周浦医院呼吸内科,上海201318 [2]上海联洋社区卫生服务中心,上海200135 [3]上海市第七人民医院急诊科,上海200137

出　　处：《临床和实验医学杂志》2013年第11期835-836,838,共3页Journal of Clinical and Experimental Medicine

基　　金：周浦医院2012年院级重点学科基金资助;浦东新区卫生科技项目青年基金资助(PW2011B-4)

摘　　要：目的研究参附注射液对脓毒症肝损伤临床疗效。方法根据脓毒症诊断标准入组68例患者,治疗组参附注射液静脉泵入,100 ml/d,共7 d。记录入组患者3 d、7 d、14 d的生存率,检测血清丙氨酸氨基转移酶(SGPT)、血清总胆红素(TBIL),同时进行急性生理与慢性健康评分Ⅱ(APACHEⅡ)评分。并进行统计分析。结果参附治疗组各组与治疗前比较SGPT、TBIL、APACHEⅡ均有明显改善(P<0.05),同时参附治疗组较对照组在实验早期SGPT水平出现明显下降(P<0.05),参附组生存率较对照组有所改善,但差异无显著性。结论参附可能对于脓毒症早期轻度肝损伤能起到一定的治疗作用,这对于脓毒症肝损伤的中西医结合治疗以及降低疾病的经济负担均有具有重要的意义。Objective To study the clinical efficacy of Shenfu injection on liver injury in sepsis.Methods According to the diagnostic criteria for sepsis,68 patients were enrolled in the treatment group.Shenfu injection was infused intravenously 100 ml / d,a total of 7 days.Records of patients enrolled in 3 d,7 d,14 d of survival,liver enzymes and bilirubin levels,APACHE II score were determined.These data were analyzed statistically.Results Compared with before treatment,the SGPT TBIL APACHE Ⅱ of Shenfu treatment groups showed significant improvement（P 0.05）.While compared with the control group in the experiment,the early SGPT levels of Shenfu treatment group decreased significantly（P 0.05）.The survival rate compared with the control group was increased.Conclusion This study showed that the Shenfu may play a therapeutic effect in early sepsis associated mild liver injury.This combined treatment for septic liver injury in Western medicine can reduce the economic burden of disease and have great significance.

关 键 词：参附注射液 脓毒症 肝损伤 

分 类 号：R278[医药卫生—中医学]