益赛普联合塞来昔布治疗强直性脊柱炎的临床疗效观察  

Study on efficacy of Etanercept and Celecoxib in treatment of patients with ankylosing spondylitis

作　　者：丁怡[1] 陈璇[2] 王颖[1] 张静女[1] 刘萍[1] 

机构地区：[1]深圳市第五人民医院风湿内科,广东深圳518001 [2]新乡医学院第三附属医院儿科,河南新乡453003

出　　处：《临床和实验医学杂志》2013年第12期917-919,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的观察益赛普联合塞来昔布治疗强直性脊柱炎(AS)的临床疗效及安全性。方法采用前瞻性研究及随机配对原则将72例AS患者分为治疗组36例和对照组36例,治疗组采用益赛普联合塞来昔布进行治疗,对照组采用塞来昔布联合柳氮磺胺吡啶治疗,16周后,对两组患者治疗前后临床观察指标和实验室指标进行评估。结果治疗后,治疗组和对照组的腰背痛程度、外周关节肿胀程度和晨僵时间比较,差异有显著性(P<0.05)。治疗组和对照组的实验室指标红细胞沉降率、C反应蛋白、TNF-α比较,差异有显著性(P<0.05)。治疗组总有效率为91.44%,对照组有效率为72.22%。两组总有效率差异有显著性(P<0.05)。结论益赛普联合塞来昔布治疗AS疗效显著,安全性好,是治疗AS的理想选择。Objective To explore the efficacy and safety of Etanercept and Celecoxib in treatment of 36 patients with ankylosing spondylitis.Methods By the prospective study method,72 patients with ankylosing spondylitis were randomly divided into trial group and control group.Thirty six patients in trial group were given with Etanercept and Celecoxib for treatment,and 36 patients in control group were treated by Celecoxib and sulfasalazine.The clinical observation index and laboratory parameters were evaluated in both 2 groups after treatment for 16 weeks.Results The severity of lower back pain,degree of peripheral joint swelling and duration for morning stiffness were compared after treatment for 16 weeks,and their difference was statistically significant（P 0.05）.Laboratory indexes including erythrocyte sedimentation rate,serum levels of C-reactive protein and TNF-α were compared,and their difference was statistically significant（P 0.05）.The total rate of effectiveness（clinical ease plus marked improvement plus effectiveness） was 91.67%（33 /36） in trial group,and effective rate of control group was 72.22%（26 / 36）.The total effective rate was compared between these 2 groups,and their difference was statistically significant（P 0.05）.Conclusion The efficacy of Etanercept and Celecoxib in treatment of patients with ankylosing spondylitis is distinct,safe and compliance,hence it is the ideal choice for treatment of patients with ankylosing spondylitis.

关 键 词：强直性脊柱炎 益赛普 塞来昔布 疗效 

分 类 号：R593.23[医药卫生—内科学]