高血压病肝阳上亢证酪氨酸羟化酶基因多态性分析  

A STUDY ON THE TYROSINE HYDROXYLASE GENE POLYMORPHISM IN HYPERTENSION WITH HYPERACTIVE LIVER YANG

作　　者：唐发清[1] 金益强[1] 鄢东红[1] 谌兵来[1] 胡随瑜[1] 刘爱平[1] 张翔[1] 肖纯[1] 王勇华[1] 

机构地区：[1]湖南医科大学湘雅医院中西医结合研究所,湖南长沙410008

出　　处：《湖南中医学院学报》2000年第2期3-4,7,共3页Journal of Hunan College of Traditional Chinese Medicine

基　　金：国家自然科学基金!资助项目 (396 70 890 )

摘　　要：为探讨高血压病肝阳上亢证与酪氨酸羟化酶基因 (TH )多态性的相关性 ,采用西医辨病和中医辨证方法选择研究对象 ,用 Southern Blot分析了肝阳上亢证、肝肾阴虚证和健康人 TH基因多态性 ,并测定了血浆去甲肾上腺素 (NE)和肾上腺素 (E)。结果表明 :高血压病肝阳上亢证患者血浆 NE、E含量明显高于健康人组和肝肾阴虚证组 (P<0 .0 5 ) ,高血压病肝阳上亢证 TH基因有显著扩增 (P<0 .0 5 )。提示高血压病肝阳上亢证的形成可能与Objective:To investigate the characteristic tyrosine hydroxylase polymorphism of human hypertension with hyperactive Liver-yang.Method:Southern Blot was used to test the tyrosine hydroxylase gene polymorphism of human hypertension with hyperactive Liver-yang and measure the norepinehrine and epinehrine in blood.Results:The norepinehrine and epinehrine of human hypertension with hyperactive Liver-yang were higher than those of the normal group and Liver-kidney ying deficiency group(P<0 05).There was tyrosine hydroxylase gene polymorphism in human hypertension with hyperactive Live-yang(P<0 05).Conclusion:The development of the hyperactivity of the Liver yang is linked with tyrosine hydroxylase polymorphism.

关 键 词：高血压 肝阳上亢证 酷氨酸羟化酶 基因多态性 

分 类 号：R259.441[医药卫生—中西医结合] R544.1[医药卫生—中医内科学]