复方地西泮鼻腔给药的安全性评价  

Nasal mucosa and mucociliary toxicity of intranasal administration of compound recipe diazepam

作　　者：盛平[1,2] 张瑞涛[3] 王晖[4] 黄钊[4] 傅晓华[1,2] 

机构地区：[1]广东药学院附属第二医院 [2]广州新海医院 [3]三峡大学医学院 [4]广东药学院中药学院

出　　处：《中国临床药理学与治疗学》2013年第5期487-490,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：广东省科技计划项目(2011B080702004)

摘　　要：目的:考察地西泮与薄荷醇配伍鼻腔给药的鼻黏膜毒性,探讨地西泮鼻腔给药的可行性。方法:以家兔鼻黏膜为研究对象,考察地西泮单用、地西泮与薄荷醇伍用给药1周和停药1周后,对家兔鼻黏膜细胞形态结构的影响及恢复情况。结果:病理组织切片显示,地西泮单用组和地西泮与薄荷醇伍用组鼻腔给药1周后,大鼠鼻黏膜细胞上皮层厚度无明显改变。停药1周后,光学显微镜观察鼻黏膜损伤的情况有所恢复。结论:地西泮单独鼻腔给药、薄荷醇单独鼻腔给药、地西泮和薄荷醇配伍鼻腔给药后,对黏膜的毒性轻微且毒性具有可逆性。AIM：To study the nasal mucosa and mucociliary toxicity of intranasal administration of diazepam and diazepam compounded with menthol.METHODS：The rabbit nasal mucosa model was established by nasal administration with diazepam and its compound recipe containing menthol for a week.Then we investigated the effects on cellular morphology of the nasal mucosa and its recovery after drug withdrawal.RESULTS：The results of histopathologic slide showed that the thickness of epithelial layers had no obvious change when the rabbit model had been applied with diazepam and its compound recipe for a week.After drug withdrawal,the injury of mucociliary was recovered to some extent.CONCLUSION：Diazepam,menthol and their compound recipe,after intranasal administration,have mild toxicity and the negative effect can be reversible on the nasal mucosa.

关 键 词：地西泮 薄荷醇 鼻腔给药 黏膜 安全性 

分 类 号：R965.2[医药卫生—药理学]