抗氧化应激在高血压治疗中的应用  

Application of antioxidant stress in the therapy of hypertension

作　　者：刘小丽[1,2] 袁洪[1,2,3] 黄志军[1,3] 李莹[1,3] 

机构地区：[1]中南大学湘雅三医院临床药理中心 [2]中南大学药学院 [3]中南大学药物临床评价研究中心

出　　处：《中国临床药理学与治疗学》2013年第5期580-585,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家"重大新药创制"科技重大专项(2012ZX09303014-001);重大基础研究前期研究专项(2011CB512001)

摘　　要：高血压是最常见的心血管疾病之一。近年来大量研究表明,氧化应激是血管损伤的主要原因,可能是导致高血压的重要病理机制。活性氧簇(Reactive oxygen species,ROS)水平的升高,导致氧化应激水平增加,诱导血压升高。高血压进一步促进ROS生成,导致组织氧化损伤。近年来抗氧化应激在心血管疾病治疗中的应用引起了国内外众多研究者关注,并且抗氧化应激在高血压治疗的临床应用方面取得了一定成效。本文主要就氧化应激导致高血压的机制及抗氧化应激治疗展开综述。Hypertension is one of the most common cardiovascular diseases.In recent years,a large number of studies have shown that oxidative stress is the main reason for the vascular injury,which may be an important pathological mechanism that can lead to hypertension.The increasing level of reactive oxygen species（ROS）,leading to increased oxidative stress induced an increase in blood pressure.Hypertension will further promote the generation of ROS,leading to tissue oxidative injury.Recently,the anti-oxidative stress therapy research attracted the attention of many researchers at home and abroad.The clinical application of oxidative stress in the treatment of hypertension have achieved certain results.The aim of the present review is to describe the contribution of oxidative stress to hypertension and anti-oxidative stress pharmacotherapy.

关 键 词：氧化应激 活性氧 高血压 治疗 

分 类 号：R544[医药卫生—心血管疾病]