苦碟子注射液对原发性肾病综合征临床疗效的观察  

Effect of Kudiezi Injection in the Treatment of Primary Nephritic Syndrome

作　　者：钟晓娟[1] 周伟东[1] 黄波[1] 潘金英[1] 姚俐[1] 王艳靖[1] 

机构地区：[1]南方医科大学珠江医院中西医结合肾病中心,广州510282

出　　处：《数理医药学杂志》2013年第3期292-294,共3页Journal of Mathematical Medicine

摘　　要：目的:探讨苦碟子注射液对原发性肾病综合征患者尿蛋白、血脂、凝血状态的影响。方法将43例确诊为原发性肾病综合征的患者随机分为两组:用药组(予以苦碟子注射液)23例,对照组20例。两组患者均接受激素或联合环磷酰胺(CTX)治疗。用药组的苦碟子注射液与激素同时使用,静脉滴注,1次/日,连用4周。结果:用药组患者24小时尿蛋白、血清白蛋白、血液中脂类代谢指标、D-二聚体浓度恢复正常速度与对照组相比均明显加快,差异有显著性意义(P<0.047),肌酐及尿素氮用药组与对照组无差异(P>0.05)。结论:苦碟子注射液可以加快原发性肾病综合征患者24小时尿蛋白、血清白蛋白、血脂、凝血功能恢复正常速度。Objective. To observe the effect of Kudiezi injection on urinary protein, serum lipids, blood coagulation of patiens with primary nephritic syndrome（PNS）. Methods： 43 patiens with PNS were random- ized divided into 2 groups：drug group（n=23）and control group（n=20）. Two groups both received treatment of corticosteroids or combination with cyclophosphamide（CTX）. Drug group received Kudiezi injection qd for 4 weeks when used corticosteroids or CTX. Results. 24 hour urine protein, serum albumin, lipid metabolism and D-Dimer concentration of drug group become normal more quikly than the control group（P〈0. 05）. The BUN,Scr of the 2 groups were not statistically significant（P〉0. 05）. Conclusion： Kudiezi injection can in- crease the speed of PNS patients＇ 24 hour urine protein, serum-albumin, lipid metabolism and D--Dimer con- centration to be normal.

关 键 词：苦碟子注射液 肾病综合征 尿蛋白 白蛋白 

分 类 号：R203[医药卫生—中医学]