苦参生物碱提取工艺研究进展  

Progress of Extraction of Alkaloids from Sophora Flavescens Ait.

作　　者：杨霄[1] 于喜水[2] 金哲雄[1] 

机构地区：[1]哈尔滨商业大学药学院,哈尔滨150076 [2]黑龙江省药品审评认证中心,哈尔滨150090

出　　处：《黑龙江医药》2013年第3期425-427,共3页Heilongjiang Medicine journal

基　　金："十五"国家重大科技专项;课题编号:2001BA701A36-13;黑龙江省科技计划项目;课题编号:GB09C314

摘　　要：苦参是一种具有广泛药理活性和应用价值的传统中药,主要含有喹诺里西啶类生物碱、异戊烯基类黄酮和齐墩果烯型三萜等成分,其中含量最高、药理活性和药用价值较突出的成分是苦参碱和氧化苦参碱。提取、分离苦参中的生物碱,并对其进行深入的工艺、药理、药效和生物利用度等方面的系统研究均具有重要的意义。本文对近年来苦参生物碱提取纯化工艺进行了综述和评价,为更好地开发和利用苦参生物碱提供依据,并对其发展前景进行了展望。Sophora flavescens Ait. is the traditional Chinese medicine of wide pharmacological activities andd application value, It mainly contains Gordon quinolone west organism alkaloids, isoamyl alkenyl flavonoids and olea olefinic type triterpenoid, etc. Among them the highest content, pharmacological activity and medicinal value more prominent components are matrine and oxymatrine,extracting and separating alkaloids from Sophora fIaveseens, and carries out in depth systematic studies on its teehnoIogy, pharmacoiogy, drug effect and bioiogical utilization. In this paper the extraction and purification process of alkaloidal from sophraflavseens Air .were presented in recent years, and gives the corresponding evaluation, in order to the better development and use of Sophocarpidine provide reference. Fi-nally, development prospect in future were analyzed.

关 键 词：苦参 生物碱 提取工艺 

分 类 号：TQ461[化学工程—制药化工]