注射用加替沙星与注射用头孢地嗪钠配伍稳定性考察  

Study on the Compatibility of Gatifloxacin and Cefodizime Sodium for Injection by High Performance Liquid Chromatography

作　　者：杨继章[1] 刘瑞琴[1] 张辰辰[2] 

机构地区：[1]河北医科大学第一医院河北省脑老化与认知神经科学实验室,石家庄050031 [2]河北医科大学药学院,石家庄050017

出　　处：《医药导报》2013年第6期793-795,共3页Herald of Medicine

基　　金：河北省医学科学研究重点课题(04177)

摘　　要：目的考察注射用加替沙星与注射用头孢地嗪钠分别在0.9%氯化钠注射液和5%葡萄糖注射液中配伍的稳定性。方法在室温(20±1)℃,观察两药配伍后的外观、pH、含量变化,高效液相色谱法测定配伍液中加替沙星和头孢地嗪钠含量。结果两药配伍后6 h内的外观、pH、含量均无明显变化。结论在室温条件下,注射用加替沙星与注射用头孢地嗪钠在0.9%氯化钠注射液和5%葡萄糖注射液中配伍稳定。Objective To study the compatibility of gatifloxacin for injection and cefodizime sodium for injection in 0.9% sodium chloride or 5% glucose. Methods An high performance liquid chromatography （HPLC） method was used to study the content changes after mixture of gatifloxacin and cefodizime sodium after storage at room temperature （20± 1 ） ℃ for 6 h. Changes of the physical appearance and the pH in the admixture were also examined. Results No significant change in drug content, pH, or physical appearance was found after 6 h. Conclusion Gatifloxacin for injection can be mixed with cefodizime sodium for injection in 0.9% sodium chloride or 5% glucose.

关 键 词：加替沙星 头孢地嗪 配伍 稳定性 色谱法 高效液相 

分 类 号：R978[医药卫生—药品] R969.3[医药卫生—药学]