利用氢化物发生-冷阱捕集-原子吸收光谱联用技术测定雄黄染毒大鼠血中砷的含量  

Determination of arsenic species in blood of rats treated with realgar by hydride generation-cryogenic trapping-atomic absorption spectrophotometry

作　　者：张颖花[1] 高咏[2] 霍韬光[1] 姜泓[1] 孙贵范[1,3] 

机构地区：[1]中国医科大学公共卫生学院,辽宁沈阳110001 [2]沈阳市食品药品检验所,辽宁沈阳110013 [3]辽宁省砷生物学作用与砷中毒重点实验室,辽宁沈阳110001

出　　处：《化学研究》2013年第3期274-276,共3页Chemical Research

基　　金：国家自然科学基金资助项目(81073144);中国博士后科学基金面上资助项目(2012M510848)

摘　　要：采用氢化物发生-冷阱捕集-原子吸收光谱法(HG-CT-AAS)测定了雄黄染毒大鼠血中不同形态砷的含量.结果表明,雄黄在大鼠体内的代谢产物为无机砷、一甲基胂酸和二甲基胂酸,其中二甲基胂酸是主要代谢产物;3种形态砷的精密度、准确度、回收率及线性关系良好.The content of arsenic species in the blood of rats treated with realgar was analyzed by means of automated hydride generation-cryogenic trapping-atomic absorption spectropho- tometry （HG-CT-AAS）. Results show that the metabolic products of realgar in the body of rats include inorganic arsenic, monomethyl arsenic acid and dimethyl arsenic acid, in which dimethyl arsenic acid is the predominant arsenic species. Besides, various arsenic species can be well separated and determined by established HG-CT-AAS method with a good precision, accu- racy, recovery and linearity.

关 键 词：雄黄 砷 氢化物发生-冷阱捕集-原子吸收光谱法 测定 

分 类 号：O613.63[理学—无机化学]