心肌肽素的分离组分及组分相加对阿霉素中毒大鼠心肌细胞的修复作用  

Recovery Effect of Cardiomyopeptidin Fractions and Fraction Addition on Cardiac Muscle Cells in Rats Damaged by Adriamycin

作　　者：杨联萍[1] 孔祥平[1] 李茹冰[1] 曾平鲁[1] 

机构地区：[1]中国人民解放军第458医院传染病中心分子生物学科,广东广州510602

出　　处：《中国中药杂志》2000年第6期362-363,共2页China Journal of Chinese Materia Medica

基　　金："九五"国家重点科技攻关项目!(96 ;90 2 0 1 0 4 )

摘　　要：目的 :研究心肌肽素的分离组分及组分相加对阿霉素中毒大鼠心肌细胞的修复作用。方法 :采用MTT比色法 ,观察阿霉素中毒心肌细胞内线粒体琥珀酸脱氢酶的活力。结果 :心肌肽素及 5个分离组分均显示了促进琥珀酸脱氢酶活力的作用 ,其中P1组分活力较强 ;各组分相加亦显示促进酶活力的作用 ,但未见显示相加效应。结论 :心肌肽素对阿霉素所致心肌细胞损伤的促进修复作用 ,系各组分所含物共同作用的结果。Objective:To investigate the recovery effect of cardiomyopeptidin fractions and fraction addition on the cardiac muscle cells in rats damaged by adriamycin.Methods:Observing the activity of the succinic dehydrogenase which is at mitochondrion in the cells damaged by adriamycin with MTT.Results:Five fractions have all promoted the activating effect of the enzyme, the action of P1 being higher than the others.Fraction addition has also promoted the activating effect of the enzyme,but whithout additive effect.Conclusion:The recovery effect of cardimyopeptidin depends on the interplay among the fractions. [

关 键 词：心肌肽素 阿霉素 细胞培养 分离组分 

分 类 号：R285[医药卫生—中药学]