强生液延缓衰老作用的研究  

Studies on Senility retarding Effect of Qiangshengye Liguid

作　　者：杨秋生[1] 赵蕙兰 陈林[2] 

机构地区：[1]首都医科大学药理教研室,北京100054 [2]株洲武警部队医院,湖南株洲410400

出　　处：《中国中药杂志》2000年第6期367-369,共3页China Journal of Chinese Materia Medica

摘　　要：目的 :观察强生液延缓衰老的作用。方法 :以强生液 3.3,6 .6 g·kg-1连续灌胃各组大鼠 2 1d后 ,用光化学扩增法和硫代巴比妥酸法 (TBA)分别测定红细胞超氧化歧化酶 (SOD)活性和肝、血浆过氧化脂质 (LPO)含量 ,用荧光偏振法测定红细胞膜流动性。此处 ,还观察了强生液对小鼠耐缺氧、耐疲劳及耐高温的影响。结果 :强生液6 .6g·kg-1可提高高龄大鼠红细胞SOD活性 (P <0 .0 5 ) ,明显降低血浆及肝脏LPO含量 (P <0 .0 5 ,P <0 .0 1) ,两个剂量组均可提高红细胞膜流动性 (P <0 .0 5 ) ,并可延长小鼠耐缺氧、耐疲劳及耐高温存活时间。结论 :强生液有良好的抗氧化作用 ,提示其有一定的抗疲劳、延缓衰老功效。Objective:To observe the effect of Qiangshengye liquid on senility retarding in rats.Methods:The liquid was orally administrated to rats at doses of 3.3 g·kg -1 and 6.6 g·kg -1 , and after Twenty one days the activity of superoxide dismutase (SOD) in red blood cells and lipid peroxide(LPO)in plasma and in liver were examined respectively by spectrophotometry.Fluorescence polarization was used to evaluate the fluidity of erythrocyte membrane.In addition the anti fatigue effect of the liquid in mice was detected.Results:The liquid can significantly increase the activity of SOD( P <0.05)in red blood cells and decrease the contents of LPO in plasma( P <0.05)and in liver( P <0.01). The fluidity of erythrocyte membrane was also improved ( P <0.05).Conclusion:Qiangshengye liquid can antagonize lipid peroxidation and therefore may be used for anti fatigue and senility retarding purposes. [

关 键 词：强生液 超氧化物歧化酶 过氧化脂质 延缓衰老 

分 类 号：R285.05[医药卫生—中药学]