厄贝沙坦联合银杏达莫注射液治疗48例早期糖尿病肾病的疗效分析  

Analysis of the Efficacy of Irbesartan Combined with Ginkgo Dipyridamolum Injection for the Treatment of 48 Patients with Early Diabetic Nephropathy

作　　者：张春娟[1] 李红妹[1] 石芳[1] 宋桂菊[1] 

机构地区：[1]河北省冀州市医院内一科,河北冀州053200

出　　处：《医学临床研究》2013年第5期850-853,共4页Journal of Clinical Research

摘　　要：【目的】探讨早期糖尿病肾病（DN）的治疗方法及厄贝沙坦联合银杏达莫注射液对DN的临床疗效。【方法】本院收治的DN患者48例，按随机数字表将其分为对照组和观察组，两组各24例。对照组在行常规饮食治疗和控制血糖等的同时，给予厄贝沙坦治疗，观察组在对照组治疗基础上加用银杏达莫注射液，治疗后观察和比较两组临床疗效、治疗前后生化指标、血液流变学指标以及不良反应。【结果】观察组DN患者总有效率达到91．67％，显著高于对照组（P〈O．05）；治疗后总胆固醇（Tc）、空腹血糖（FBG）、血清肌酐（SCr）、血尿素氮（BUN）、尿微量白蛋白排泄率（UAER）和糖化血红蛋白（HbAlc）水平较治疗前均显著降低（P〈0．05），其中TC、SCr、BUN、UAER和HbAlc水平显著低于照组治疗后水平（P〈0．05）；治疗后血浆黏度（曲）、血细胞比容（Hot）、全血低切、全血高切以及DBP和SBP水平显著低于治疗前和对照组治疗后水平（P〈O．05）；总不良反应率为8．33％（2／24），显著低于对照组的20．83％（P〈O．05）。【结论】在厄贝沙坦基础上联合银杏达莫注射液，能显著降低DN患者血糖、血压、减缓UAER排泄，改善血液流变学指标，不良反应少，临床效果显著。[Objective]To explore the treatment method of early diabetic nephropathy（DN） and clinical ef- ficacy of irbesartan combined with ginkgo dipyridamolum injection for the treatment of DN. [Methods] A total of 48 DN patients admitted to our hospital from Jan. 2011 to Oct. 2012 were chosen and randomly divided into control group（ n = 24） and observation group（n= 24）. The control group was given irbesartan based on the routine diet treatment and glycemic control. The observation group was treated with ginkgo dipyridamolum in- jection based on the treatment of control group. Clinical efficacy after treatment, the biochemical indexes, the parameters of blood rheology and the adverse reaction of two groups before and after treatment were observed and compared. [Results] The total effective rate of DN patients in observation group was 91.67%, which was significantly higher than that in control group（ P 〈0.05）, but inefficiency rate was 8.33%, which was significantly lower than that in control group（ P 〈0.05）. The levels of TC, FBG, Scr, BUN, UAER and HbAlc in observation group were significantly lower than those in control group after treatment （ P 〈0.05）. The TC, Scr, BUN, UAER and HbAlc of the observation group after treatment were significantly lower than the control group after treatment （ P 〈0.05）. The levels of Hct, ηB, blood low shear, blood high shear, DBP and SBP after treatment were significantly lower than those in control group and before treatment（ P d0.05）. The total adverse reaction rate in observation group was 8.33~ （2/24）, which was significantly lower than that in control group（ P d0.05）. [Conclusion] Irbesartan combined with ginkgo dipyridamolum injection can significantly reduce blood glucose and blood pressure, and slow down the excretion of UAER of DN patients, and improve blood theology indices with less adverse reactions. The clinical efficacy is significant.

关 键 词：糖尿病肾病 药物疗法 银杏 投药和剂量 

分 类 号：R587.24[医药卫生—内分泌]