冠心病患者血清γ-谷氨酰转移酶及丙二醛检测的临床意义  

Clinical Significance of Serum Malondialdehyde and Gamma-glutamyl Transferase in Patients with Coronary Heart Disease

作　　者：曹国良[1] 凌丹芸[1] 李晓丽[1] 俞建华[2] 刘新兵[2] 冯月英[1] 王传慧[1] 

机构地区：[1]上海交通大学医学院附属第三人民医院老年科,上海201900 [2]上海市杨浦区市东医院心内科,上海200438

出　　处：《医学临床研究》2013年第5期891-893,共3页Journal of Clinical Research

摘　　要：【目的】观察血清γ谷氨酰转移酶（GGT）和血浆丙二醛（MDA）在冠心病人群中的变化，探讨GGT和MDA在冠心痛患者中的临床意义。【方法】选择冠脉造影确诊的冠心病患者及对照组共157例，分成四组，对照组40例，稳定型心绞痛（SAP组）38例，非ST抬高型急性冠脉综合征（NSTE-ACS组）41例和ST抬高型急性冠脉综合征（STE—ACS组）40例，分别测定其GGT、MAD水平并进行组问比较。【结果】NSTE—ACS组和STE-ACS组中GGT、MAD明显高于对照组及SAP组（P〈0．01）。【结论】氧化应激参与急性冠脉综合征的病理生理过程，抗氧化治疗可能对冠心病治疗有重要意义。[Objective] To observe the change of serum malondialdehyde（MDA） and gamma-glutamyl transferase（GGT） in patients with coronary heart disease and to explore the clinical significance of MDA and GGT in patients with coronary heart disease. [Methods] A total of 157 patients with coronary heart disease confirmed by coronary angiography were divided into 4 groups including control group（ n = 40）, stable angina pectoris group（SAP group, n ~ 38）, non-ST-segment elevation acute coronary syndrome group （NSTE-ACS group, n =41） and ST-segment elevation acute coronary syndrome group（STE-ACS group, n = 40）. Plasma levels of MDA and GGT were measured and compared among groups. [Results] Plasma levels of MDA and GGT in NSTE-ACS group and STE-ACS group were significantly higher than those in control group and SAP group（ P 〈0.01）. [Conclusion] Oxidative stress participates the pathological process of acute coronary syndrome. Anti-oxidation therapy may be important to the treatment of coronary heart disease.

关 键 词：冠心病 血液 Γ谷氨酰转移酶 血液 丙二醛 血液 

分 类 号：R541.4[医药卫生—心血管疾病]