中国人VEGF基因多态性与DR的关系  

The association study of gene polymorphism of vascular endothelial growth factor with diabetic retinopathy

作　　者：李东豪[1] 胡利[1] 何文智[2] 丘红红[1] 闻毅颐[1] 杨倩[1] 

机构地区：[1]广州医学院第三附属医院眼科,中国广东省广州市510150 [2]广州医学院第三附属医院妇研所实验室,中国广东省广州市510150

出　　处：《国际眼科杂志》2013年第6期1106-1107,共2页International Eye Science

基　　金：广州市荔湾区科技计划项目(No.20111213068)~~

摘　　要：目的:探讨血管内皮生长因子(vascular endothelial growth factor,VEGF)I/D基因多态性与糖尿病视网膜病变(diabetic retinopathy,DR)的关系。方法:应用PCR-RFLP方法检测91例2型糖尿病患者和30例对照者的VEGF I/D基因和VEGF水平。结果:NPDR组和PDR组DD基因型频率显著高于NDR组和对照组(P<0.01);NPDR组和PDR组血清VEGF水平显著高于NDR组和对照组(P<0.01)。结论:VEGF I/D基因多态性很可能与DR的发生发展有关,D等位基因可能是DR的易感基因。AIM： To investigate the correlation of vascular endothelial factor （VEGF） I/D gene polymorphism with diabetic retinopathy（DR） in type 2 diabetes mellitus. METHODS： The 91 patients with diabetes and 30 control cases which VEGF I/D genotypes and VEGF level were determined by polymerase chain reaction - restriction fragment length polymorphism（PCR-RFLP）. RESULTS： The DD genotype frequencies were significantly higher in NPDR and PDR groups than in groups of NDR and control （P〈 0.01 ） ; The VEGF level were significantly higher in NPDR and PDR groups than in groups of NDR and normal control（ P〈0.01 ）. CONCLUSION： VEGF I/D gene polymorphism is associated with the development of diabetic retinopathy; D allele is probably a susceptible gene of diabetic retinopathv.

关 键 词：血管内皮 生长因子 基因多态性 糖尿病视网膜病变 

分 类 号：R587.1[医药卫生—内分泌] R774.1[医药卫生—内科学]