骨髓增生异常综合征患者MRI检查心脏T2＊值与心脏铁过载关系的初步探讨  

Correlation of cardiac T2＊ value with cardiac iron overload in myelodysplastic syndrome patients

作　　者：肖超[1,2] 顾树程[2] 张曦[2] 赵佑山[2] 常春康[2] 

机构地区：[1]苏州大学医学部,江苏苏州215006 [2]上海交通大学附属第六人民医院血液科,上海200233

出　　处：《诊断学理论与实践》2013年第1期28-31,共4页Journal of Diagnostics Concepts & Practice

摘　　要：目的:检测骨髓增生异常综合征(MDS)患者MRI检查中心脏T2*值和心脏铁过载的相关指标——左心室射血分数(LVEF),并探讨心脏T2*值与心脏功能的关系。方法:20例MDS患者行MRI检查,得到心脏、肝脏T2*数值,并换算成心铁、肝铁浓度(LIC),同时进行心脏超声检测,得到LVEF。结果 :MDS患者的心脏T2*值与LVEF间存在相关性(r=0.565,P=0.009),而心脏T2*值与国际预后积分系统(IPSS)评分、患者病程时间、LIC、SF间则均无相关性(P>0.05)。不同WHO分型、IPSS分层、性别、是否输血、近一年输血量患者间的心脏T2*值无统计学差异。结论:心脏T2*值对MDS患者心脏功能有一定预测性,比同期的LIC及血清铁蛋白可能更有价值。Objective To determine the cardiac T2＊ value of magnetic resonance imaging and the related index of cardiac iron overload-left ventricular ejection fraction in myelodysplastic syndrome patients and analyze the relationship between cardiac T2＊ value and cardiac function. Methods Cardiac T2＊ and liver T2＊ value were measured by MRI examination in 20 MDS patients, MIC （myocardial iron concentration） and LIC （liver iron concentration） were calculated from cardiac T2＊ and liver T2＊, respectively. And LYEF （left ventricular ejection fraction） was measured by echocardiographic examination. Results Correlation of cardiac T2＊ value with LVEF was statistically significant （r=-0.565, P=0.009）. However, cardiac T2＊ value had no correlation with WHO classification, IPSS score, gender, blood transfusion, disease time, LIC and SF （serum ferritin）. Conclusions Cardiac T2＊ value has considerable predictability for cardiac function and is superior to serum ferritin and liver iron.

关 键 词：骨髓增生异常综合征 磁共振成像 心脏T2＊值 心脏铁过载 左心室射血分数 相关性 

分 类 号：R551.3[医药卫生—血液循环系统疾病]