MAOA-uVNTR多态性与学步期儿童内隐问题行为的关系  

Relation between MAOA-uVNTR polymorphism and internalizing problem behaviors of toddlers

作　　者：汪志鹏[1,2] 刘亚鹏[1] 张明浩[1,3,4] 陈平[1] 张光珍[1] 梁宗保[1] 邓慧华[1] 陆祖宏[1,2] 

机构地区：[1]东南大学学习科学研究中心,山东烟台264000 [2]东南大学生物科学与医学工程学院,江苏南京210096 [3]东南大学 [4]鲁东大学心理学院,山东烟台264000

出　　处：《东南大学学报（医学版）》2013年第3期293-296,共4页Journal of Southeast University(Medical Science Edition)

基　　金：教育部科技创新工程重大项目(704025)

摘　　要：目的:探究MAOA基因重复片段多态性对学步期儿童内隐问题行为的影响。方法:以295名学步期儿童为研究对象,在儿童6个月时,采集口腔脱落细胞,24个月时由父母报告其内隐问题行为。结果:拥有3型MAOA基因的男孩抑郁、焦虑以及内隐问题行为的水平与4型男孩的水平相比较差异无统计学意义(P>0.05);拥有4/4型MAOA基因的女孩,其抑郁、焦虑以及内隐问题行为的水平与3/3+3/4型女孩差异无统计学意义(P>0.05)。结论:这表明MAOA-uVNTR多态性对学步期儿童抑郁、焦虑以及内隐问题行为均没有显著影响。Objective： Toddler＇s internalizing problem behaviors is one of the important results of children＇s socialization.It will give rise to the negative effect on children＇s learning,psychological health and personality development.This study aims to investigate the effects of MAOA-uVNTR polymorphism on internalizing problem behaviors of 295 toddlers. Methods： When toddlers aged 6 months,their cheek cells were collected and their internalizing problem behaviors were reported by their parents at the age of 24 months. Results： It was found that boys with 3 genotypes don＇t differ in the level of depression,anxiety and internalizing problem behaviors from that of boys with 4 genotypes significantly.The level of depression,anxiety and internalizing problem behaviors of girls with 3/3 and 3/4 genotypes shows no difference with that of girls with 4/4 genotypes. Conclusion： These results suggest that MAOA-uVNTR polymorphism do not play a role in boy＇s or girl＇s depression,anxiety and internalizing problem behaviors.

关 键 词：MAOA-uVNTR多态性 学步期儿童 内隐问题行为 抑郁 焦虑 

分 类 号：R174[医药卫生—妇幼卫生保健] R395.2[医药卫生—公共卫生与预防医学]