北方汉族Grave病与HLA相关性研究  

The Study of Grave Disease Associated with HLA in Northern Han Chinese

作　　者：鲁梅花[1] 邵文硕[1] 

机构地区：[1]首都医科大学宣武医院内分泌科

出　　处：《首都医科大学学报》2000年第2期122-124,共3页Journal of Capital Medical University

摘　　要：利用序列特异性寡核苷酸引物多聚酶链反应 (PCR/SSP)的方法 ,对北方汉族 4 2例Grave病患者及 52例正常对照组的HLA DR2、DR3的分布频率进行了分析。结果 :Grave病患者组HLA DR3抗原的频率明显高于正常对照组 (P <0 .0 5) ,相对危险度为 3.84 ,而HLA DR2抗原的频率在 2组间无明显差异 (P >0 .0 5)。提示 :HLA DR3与北方汉族Grave病的发病有相关性。Northern Han Chinese patients with Grave disease and 52 healthy controls were randomly chosen. Ploymerase chain reaction and sequence specific primer (PCR/SSP) were used to determine the frequency of HLA DR2 and DR3. The frequency of DR3 was increased in Grave disease patients, the relative risk ( RR ) was 3.84( P <0.05). The RR of DR2 was 1.16( P >0.05). The above results suggested that HLA DR3 is associated with Grave disease in Northern Han Chinese.

关 键 词：GRAVE病 HLA 聚合酶链反应 相关性研究 

分 类 号：R581.1[医药卫生—内分泌]