大剂量甲氨蝶呤治疗急性淋巴细胞白血病的不良反应及护理对策  

Adverse reactions and nursing strategy of high-dose methotrexate in the treatment of acute lymphoblastic leukemia

作　　者：王平[1] 李艳玲[1] 曹志新[1] 

机构地区：[1]河北大学附属医院血液内科,保定071000

出　　处：《中国肿瘤临床与康复》2013年第5期527-529,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的观察大剂量甲氨蝶呤治疗急性淋巴细胞白血病的不良反应并探讨有效的护理对策。方法选择2010年9月至2012年8月收治的急性淋巴细胞白血病患者82例作为研究对象,按照随机数字表法分为两组,对照组40例、观察组42例,两组均采用大剂量甲氨蝶呤治疗,同时对照组采用常规护理方法,观察组采用循证护理模式,观察两组患者的临床康复效果和并发症发生情况。结果观察组患者治疗总有效率为95.2%,对照组为92.5%,差异无统计学意义(P>0.05);观察组患者术后并发症发生率为19.0%,明显低于对照组的42.5%,差异有统计学意义(P<0.05)。结论大剂量甲氨蝶呤是治疗急性淋巴细胞白血病的有效药物,对采用该治疗方案的患者采用循证护理模式可以明显降低不良反应发生率,值得临床借鉴。Objective To observe the adverse reactions and nursing strategy of high-dose methotrexate in the treatment of acute lymphoblastic leukemia and explore effective nursing strategy.Methods From September 2010 to August 2012 in our hospital,82 patients with acute lymphoblastic leukemia were selected and were randomly divided into two groups,40 cases of the control group and 42 cases of observation group,they were treated with high-dose methotrexate,and the control group used conventional nursing methods,the observation group used evidence-based nursing mode,the clinical effect of rehabilitation and the incidence of complications situation of two groups were compared.Results The total effective rate of observation group was 95.2%,and the control group was 92.5%,the difference was not statistically significant between the groups（P 0.05）;the complication rate of observation group was 19.0%,significantly lower than 42.5% of the control group,the difference was statistically significant between the groups（P 0.05）.Conclusions High-dose methotrexate is effective drugs for the treatment of acute lymphoblastic leukemia,evidence-based nursing mode for patients with the treatment options can significantly reduce the incidence of adverse reactions,it is worth for clinical reference.

关 键 词：急性淋巴细胞白血病 甲氨蝶呤 不良反应 护理对策 

分 类 号：R473.73[医药卫生—护理学]